Spots Global Cancer Trial Database for Genetic Basis of Melanocytic Nevi
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Trial Identification
Brief Title: Genetic Basis of Melanocytic Nevi
Official Title: Genetic Basis of Melanocytic Nevi
Study ID: NCT03054584
Conditions
Interventions
Study Description
Brief Summary: The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of California-Davis, Department of Dermatology, Sacramento, California, United States
Contact Details
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