Spots Global Cancer Trial Database for Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma
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Trial Identification
Brief Title: Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma
Official Title: Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma
Study ID: NCT05307289
Conditions
Interventions
Study Description
Brief Summary: Among the mechanisms responsible for resistance to immunotherapy, metabolism seems to play a major role. A better understanding of tumor metabolism appears to be absolutely necessary in order to propose efficient therapeutic alternatives to target tumor cells without exerting a deleterious effect on the cells responsible for the anti-tumor immune response. The main objective is to evaluate metabolism modulations in melanoma cells extracted from metastases of patients sensitive and resistant to immunotherapies (anti-PD1 or anti-PD1+anti-CTLA4).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
CHU de Nice, Nice, Alpes-maritimes, France
Contact Details
Name: Montaudie Henri
Affiliation: CHU de Nice, Service de Dermatologie
Role: PRINCIPAL_INVESTIGATOR
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