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Spots Global Cancer Trial Database for Riluzole in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

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Trial Identification

Brief Title: Riluzole in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

Official Title: A Phase II Trial of Riluzole in Patients With Advanced Melanoma

Study ID: NCT00866840

Conditions

Melanoma (Skin)

Interventions

riluzole

Study Description

Brief Summary: RATIONALE: Riluzole may stop or slow the growth of tumor cells and may be an effective treatment for melanoma. PURPOSE: This phase II trial is studying how well riluzole works in treating patients with stage III or stage IV melanoma that cannot be removed by surgery.

Detailed Description: OBJECTIVES: Primary * Determine whether administration of a daily dose of riluzole results in tumor shrinkage, as measured by RECIST criteria, in patients with advanced melanoma. Secondary * Determine the long-term toxicity of riluzole when administered to these patients. * Compare the survival of these patients with historical controls. OUTLINE: Patients receive oral riluzole twice daily on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

Contact Details

Name: James S. Goydos, MD

Affiliation: Rutgers Cancer Institute of New Jersey

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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