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Brief Title: A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
Official Title: A Randomized, Double-Blind Phase 2/3 Study of Relatlimab Combined With Nivolumab Versus Nivolumab in Participants With Previously Untreated Metastatic or Unresectable Melanoma
Study ID: NCT03470922
Brief Summary: The purpose of this study is to determine whether relatlimab in combination with nivolumab is more effective than nivolumab by itself in treating unresectable melanoma or melanoma that has spread.
Detailed Description:
Minimum Age: 12 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0010, Tucson, Arizona, United States
Local Institution - 0020, Los Angeles, California, United States
Coastal Integrative Cancer Care, San Luis Obispo, California, United States
Local Institution - 0116, Santa Barbara, California, United States
Local Institution - 0012, Washington, District of Columbia, United States
Local Institution - 0013, Jacksonville, Florida, United States
Local Institution - 0117, Orlando, Florida, United States
Local Institution - 0007, Tampa, Florida, United States
Local Institution - 0038, Atlanta, Georgia, United States
Local Institution - 0016, Chicago, Illinois, United States
Local Institution - 0114, Fort Wayne, Indiana, United States
Local Institution - 0077, Baltimore, Maryland, United States
Local Institution - 0120, Baltimore, Maryland, United States
Local Institution - 0014, Boston, Massachusetts, United States
Local Institution - 0134, Boston, Massachusetts, United States
Local Institution - 0015, Ann Arbor, Michigan, United States
Local Institution - 0009, Minneapolis, Minnesota, United States
Local Institution - 0011, Rochester, Minnesota, United States
Local Institution - 0018, Charlotte, North Carolina, United States
Local Institution - 0019, Allentown, Pennsylvania, United States
Local Institution - 0076, Dallas, Texas, United States
Local Institution - 0008, Houston, Texas, United States
Local Institution - 0135, Buenos Aires, Distrito Federal, Argentina
Local Institution - 0002, Capital Federal, Distrito Federal, Argentina
Local Institution - 0004, Buenos Aires, , Argentina
Local Institution - 0005, Buenos Aires, , Argentina
Local Institution - 0003, Ciudad Autónoma De Buenos Aires, , Argentina
Local Institution - 0042, North Sydney, New South Wales, Australia
Local Institution - 0043, Waratah, New South Wales, Australia
Local Institution - 0041, Greenslopes, Queensland, Australia
Local Institution - 0045, Southport, Queensland, Australia
Local Institution - 0133, Bedford Park, South Australia, Australia
Local Institution - 0044, Murdoch, Western Australia, Australia
Local Institution - 0036, Graz, , Austria
Local Institution - 0037, Salzburg, , Austria
Local Institution - 0035, Wien, , Austria
Local Institution - 0047, Brussels, , Belgium
Local Institution - 0049, Bruxelles, , Belgium
Local Institution - 0048, Gent, , Belgium
Local Institution - 0058, Belo Horizonte, Minas Gerais, Brazil
Local Institution - 0057, Porto Alegre, RIO Grande DO SUL, Brazil
Local Institution - 0061, Porto Alegre, RIO Grande DO SUL, Brazil
Local Institution - 0073, Santa Cruz do Sul, RIO Grande DO SUL, Brazil
Local Institution - 0063, São Paulo, SAO Paulo, Brazil
Local Institution - 0059, Rio De Janiro, , Brazil
Local Institution - 0060, Sao Paulo, , Brazil
Local Institution - 0062, Sao Paulo, , Brazil
Local Institution - 0124, Halifax, Nova Scotia, Canada
Local Institution - 0068, Ottawa, Ontario, Canada
Local Institution - 0128, Toronto, Ontario, Canada
Local Institution - 0123, Montreal, Quebec, Canada
Local Institution - 0075, Montreal, Quebec, Canada
Local Institution - 0001, Santiago, Metropolitana, Chile
Local Institution - 0096, Medellín, Antioquia, Colombia
Local Institution - 0095, Bogota, , Colombia
Local Institution - 0105, Aarhus N, , Denmark
Local Institution - 0103, Herlev, , Denmark
Local Institution - 0104, Odense, , Denmark
Local Institution - 0100, Helsinki, Uusimaa, Finland
Local Institution - 0102, Oulu, , Finland
Local Institution - 0119, Tampere, , Finland
Local Institution - 0101, Turku, , Finland
Local Institution - 0084, Rennes, Ille-et-Vilaine, France
Local Institution - 0079, Amiens, Somme, France
Local Institution - 0080, Bordeaux Cedex, , France
Local Institution - 0085, Lille, , France
Local Institution - 0081, Marseille, , France
Local Institution - 0083, Paris, , France
Local Institution - 0078, Pierre-Benite, , France
Local Institution - 0082, Poitiers, , France
Local Institution - 0131, Tübingen, Baden-Württemberg, Germany
Local Institution - 0071, Quedlinburg, Sachsen-Anhalt, Germany
Local Institution - 0032, Buxtehude, , Germany
Local Institution - 0030, Erfurt, , Germany
Local Institution - 0027, Essen, , Germany
Local Institution - 0033, Hannover, , Germany
Local Institution - 0132, Heidelberg, , Germany
Local Institution - 0074, Homburg / Saar, , Germany
Local Institution - 0029, Köln, , Germany
Local Institution - 0028, Lubeck, , Germany
Local Institution - 0072, Mannheim, , Germany
Local Institution - 0034, Muenchen, , Germany
Local Institution - 0031, Wuerzburg, , Germany
Local Institution - 0064, Athens, , Greece
Local Institution - 0065, Thessaloniki, , Greece
Local Institution - 0086, Haifa, , Israel
Local Institution - 0088, Jerusalem, , Israel
Local Institution - 0087, Ramat-gan, , Israel
Local Institution - 0111, Torino, Piemonte, Italy
ASST Papa Giovanni XXIII - Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, , Italy
Local Institution - 0108, Milano, , Italy
Istituto Nazionale Tumori Fondazione Pascale, Napoli, , Italy
Istituto Oncologico Veneto IOV, Padova, , Italy
AOUS - Policlinico S.Maria Alle Scotte, Siena, , Italy
Local Institution - 0094, Zapopan, Jalisco, Mexico
Local Institution - 0091, Monterrey, Nuevo LEON, Mexico
Local Institution - 0093, Cancún, Quintana Roo, Mexico
Local Institution - 0092, Merida, Yucatan, Mexico
Local Institution - 0129, Veracruz, , Mexico
Local Institution - 0090, Dunedin, , New Zealand
Local Institution - 0125, Hamilton, , New Zealand
Local Institution - 0089, Tauranga, , New Zealand
Local Institution - 0121, Oslo, , Norway
Local Institution - 0040, Poznan, Wielkopolskie, Poland
Local Institution - 0039, Warszawa, , Poland
Local Institution - 0070, Cluj-Napoca, Cluj, Romania
Local Institution - 0066, Bucharest, , Romania
Local Institution - 0067, Craiova, , Romania
Local Institution - 0069, Iasi, , Romania
Local Institution - 0113, Krasnodar, , Russian Federation
Local Institution - 0127, Krasnoyarsk, , Russian Federation
Local Institution - 0112, Moscow, , Russian Federation
Local Institution - 0023, A Coruña, , Spain
Local Institution - 0024, Barcelona, , Spain
Local Institution - 0025, Barcelona, , Spain
Local Institution - 0026, Madrid, , Spain
Local Institution - 0021, San Sabastian Gipuzkoa, , Spain
Local Institution - 0022, Sevilla, , Spain
Local Institution - 0098, Goteborg, , Sweden
Local Institution - 0099, Lund, , Sweden
Local Institution - 0118, Solna, , Sweden
Local Institution - 0122, Uppsala, , Sweden
Local Institution - 0052, Bristol, Avon, United Kingdom
Local Institution - 0054, Glasgow, Dumfries & Galloway, United Kingdom
Local Institution - 0056, Swansea, Glamorgan, United Kingdom
Local Institution - 0051, London, Greater London, United Kingdom
Local Institution - 0126, Inverness, Inverness-shire, United Kingdom
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR