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Brief Title: Study of Ipilimumab (MDX-010) Monotherapy in Patients With Previously Treated Unresectable Stage III or IV Melanoma
Official Title: A Randomized, Double-Blind, Multi-center, Phase II Fixed Dose Study of Multiple Doses of Ipilimumab (MDX-010) Monotherapy in Patients With Previously Treated Unresectable Stage III or IV Melanoma
Study ID: NCT00289640
Brief Summary: The purpose of this clinical research study is to compare the best overall response rate (BORR)(as per modified WHO criteria) in patients with previously treated, therapy-refractory, or -intolerant, Stage III (unresectable) or Stage IV melanoma receiving ipilimumab doses of 0.3, 3, and 10 mg/kg. The safety of this product will also be evaluated.
Detailed Description:
Minimum Age: 16 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Arizona Cancer Center, Tucson, Arizona, United States
Wilshire Oncology Medical Group Inc, Laverne, California, United States
Scripps Cancer Center, San Diego, California, United States
The Angeles Clinic And Research Institution, Santa Monica, California, United States
Yale University School Of Medicine, New Haven, Connecticut, United States
Baptist Cancer Institute, Jacksonville, Florida, United States
Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida, United States
Md Anderson Cancer Center Orlando, Orlando, Florida, United States
Palm Beach Cancer Institute, West Palm Beach, Florida, United States
Oncology Specialists, Sc, Park Ridge, Illinois, United States
American Health Network, Indianapolis, Indiana, United States
University Of Louisville, Louisville, Kentucky, United States
Harry And Jeanette Weinberg Cancer Inst At Franklin Square, Baltimore, Maryland, United States
Hubert H. Humphrey Cancer Center, Robbinsdale, Minnesota, United States
Ellis Fischel Cancer Center, Columbia, Missouri, United States
St Joseph Oncology Inc, St Joseph, Missouri, United States
Washington University School Of Medicine, St. Louis, Missouri, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Presbyterian Hospital, Charlotte, North Carolina, United States
The Christ Hospital Cancer Center Research, Cincinnati, Ohio, United States
Cleveland Clinic, Cleveland, Ohio, United States
Providence Portland Medical Center, Portland, Oregon, United States
Cancer Centers Of The Carolinas, Greenville, South Carolina, United States
Center For Oncology Research & Treatment, P.A., Dallas, Texas, United States
Mary Crowley Medical Research Center, Dallas, Texas, United States
Local Institution, Newcastle, New South Wales, Australia
Local Institution, Brisbane, Queensland, Australia
Local Institution, Heidelberg, Victoria, Australia
Local Institution, Wodonga, Victoria, Australia
Local Institution, Brussels, , Belgium
Local Institution, Bruxelles, , Belgium
Local Institution, Bruxelles, , Belgium
Local Institution, Centro-Porto Alegre, Rio Grande Do Sul, Brazil
Local Institution, Porto Alegre, Rio Grande Do Sul, Brazil
Local Institution, Jau, Sao Paulo, Brazil
Local Institution, Sao Paulo, , Brazil
Local Institution, Calgary, Alberta, Canada
Local Institution, Edmonton, Alberta, Canada
Local Institution, Kingston, Ontario, Canada
Local Institution, Olomouc, , Czech Republic
Local Institution, Praha, , Czech Republic
Local Institution, Brest, Cedex, France
Local Institution, Clermont Ferrand, , France
Local Institution, Lyon Cedex 08, , France
Local Institution, Lyon, , France
Local Institution, Marseille Cedex 09, , France
Local Institution, Paris, , France
Local Institution, Rennes, , France
Local Institution, Toulouse, , France
Local Institution, Vandoeuvre Les Nancy, , France
Local Institution, Berlin, , Germany
Local Institution, Essen, , Germany
Local Institution, Heidelberg, , Germany
Local Institution, Jena, , Germany
Local Institution, Kiel, , Germany
Local Institution, Mannheim, , Germany
Local Institution, Wurzburg, , Germany
Local Institution, Pécs, , Hungary
Local Institution, Johannesburg, Gauteng, South Africa
Local Institution, Pretoria, Gauteng, South Africa
Local Institution, Pretoria, Gauteng, South Africa
Local Institution, Cape Town, Western Cape, South Africa