⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma

Official Title: A Phase III Randomized, Open-label Study Comparing GSK1120212 to Chemotherapy in Subjects With Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma

Study ID: NCT01245062

Conditions

Melanoma

Study Description

Brief Summary: This is a two-arm, open-label, randomized Phase III study comparing single agent GSK1120212 to chemotherapy (either dacarbazine or paclitaxel) in subjects with Stage IIIc or Stage IV malignant cutaneous melanoma. All subjects must have a BRAF mutation-positive tumour sample. Subjects who have received up to one prior regimen of chemotherapy in the advanced or metastatic melanoma setting will be enrolled into the study. Subjects with any prior BRAF or MEK inhibitor use will be excluded. Approximately 297 subjects will be enrolled with 2:1 randomization (198 subjects into the GSK1120212 arm and 99 subjects into the chemotherapy arm). The primary endpoint for the statistical analysis will be a comparison of progression free survival for subjects receiving GSK1120212 compared to chemotherapy. Subjects who have progression on chemotherapy will be offered the option to receive GSK1120212.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

GSK Investigational Site, Tucson, Arizona, United States

GSK Investigational Site, Fort Myers, Florida, United States

GSK Investigational Site, Athens, Georgia, United States

GSK Investigational Site, Marietta, Georgia, United States

GSK Investigational Site, Iowa City, Iowa, United States

GSK Investigational Site, Metairie, Louisiana, United States

GSK Investigational Site, Boston, Massachusetts, United States

GSK Investigational Site, Morristown, New Jersey, United States

GSK Investigational Site, Columbus, Ohio, United States

GSK Investigational Site, Columbia, South Carolina, United States

GSK Investigational Site, Chattanooga, Tennessee, United States

GSK Investigational Site, Memphis, Tennessee, United States

GSK Investigational Site, Nashville, Tennessee, United States

GSK Investigational Site, Ciudad Autonoma de Buenos Aires, , Argentina

GSK Investigational Site, Garran, Australian Capital Territory, Australia

GSK Investigational Site, Port Macquarie, New South Wales, Australia

GSK Investigational Site, Waratah, New South Wales, Australia

GSK Investigational Site, South Brisbane, Queensland, Australia

GSK Investigational Site, Townsville, Queensland, Australia

GSK Investigational Site, Woolloongabba, Queensland, Australia

GSK Investigational Site, Kurralta Park, South Australia, Australia

GSK Investigational Site, Woodville, South Australia, Australia

GSK Investigational Site, Heidelberg, Victoria, Australia

GSK Investigational Site, Melbourne, Victoria, Australia

GSK Investigational Site, Graz, , Austria

GSK Investigational Site, Wien, , Austria

GSK Investigational Site, Brussels, , Belgium

GSK Investigational Site, Charleroi, , Belgium

GSK Investigational Site, Gent, , Belgium

GSK Investigational Site, Jette, , Belgium

GSK Investigational Site, Kortrijk, , Belgium

GSK Investigational Site, Leuven, , Belgium

GSK Investigational Site, Wilrijk, , Belgium

GSK Investigational Site, Yvoir, , Belgium

GSK Investigational Site, Calgary, Alberta, Canada

GSK Investigational Site, Vancouver, British Columbia, Canada

GSK Investigational Site, Halifax, Nova Scotia, Canada

GSK Investigational Site, Hamilton, Ontario, Canada

GSK Investigational Site, London, Ontario, Canada

GSK Investigational Site, Oshawa, Ontario, Canada

GSK Investigational Site, Ottawa, Ontario, Canada

GSK Investigational Site, Toronto, Ontario, Canada

GSK Investigational Site, Montreal, Quebec, Canada

GSK Investigational Site, Montreal, Quebec, Canada

GSK Investigational Site, Hradec Kralove, , Czechia

GSK Investigational Site, Ostrava, , Czechia

GSK Investigational Site, Praha 2, , Czechia

GSK Investigational Site, Zlin, , Czechia

GSK Investigational Site, Boulogne-Billancourt, , France

GSK Investigational Site, Grenoble, , France

GSK Investigational Site, Montpellier, , France

GSK Investigational Site, Nantes, , France

GSK Investigational Site, Paris Cedex 10, , France

GSK Investigational Site, Pierre-Benite cedex, , France

GSK Investigational Site, Rennes, , France

GSK Investigational Site, Tours, , France

GSK Investigational Site, Villejuif, , France

GSK Investigational Site, Heidelberg, Baden-Wuerttemberg, Germany

GSK Investigational Site, Mannheim, Baden-Wuerttemberg, Germany

GSK Investigational Site, Tuebingen, Baden-Wuerttemberg, Germany

GSK Investigational Site, Muenchen, Bayern, Germany

GSK Investigational Site, Wuerzburg, Bayern, Germany

GSK Investigational Site, Buxtehude, Niedersachsen, Germany

GSK Investigational Site, Essen, Nordrhein-Westfalen, Germany

GSK Investigational Site, Dresden, Sachsen, Germany

GSK Investigational Site, Luebeck, Schleswig-Holstein, Germany

GSK Investigational Site, Berlin, , Germany

GSK Investigational Site, Athens, , Greece

GSK Investigational Site, Athens, , Greece

GSK Investigational Site, Thessaloniki, , Greece

GSK Investigational Site, Milano, Lombardia, Italy

GSK Investigational Site, Milano, Lombardia, Italy

GSK Investigational Site, Milano, Lombardia, Italy

GSK Investigational Site, Pisa, Toscana, Italy

GSK Investigational Site, Christchurch, , New Zealand

GSK Investigational Site, Dunedin, , New Zealand

GSK Investigational Site, Newtown, Wellington, , New Zealand

GSK Investigational Site, Oslo, , Norway

GSK Investigational Site, Poznan, , Poland

GSK Investigational Site, Warszawa, , Poland

GSK Investigational Site, Warszawa, , Poland

GSK Investigational Site, Chelyabinsk, , Russian Federation

GSK Investigational Site, Magnitogorsk, , Russian Federation

GSK Investigational Site, Moscow, , Russian Federation

GSK Investigational Site, St. Petersburg, , Russian Federation

GSK Investigational Site, Goteborg, , Sweden

GSK Investigational Site, Linkoping, , Sweden

GSK Investigational Site, Lund, , Sweden

GSK Investigational Site, Stockholm, , Sweden

GSK Investigational Site, Uppsala, , Sweden

GSK Investigational Site, Zurich, , Switzerland

GSK Investigational Site, Dnepropetrovsk, , Ukraine

GSK Investigational Site, Kharkiv, , Ukraine

GSK Investigational Site, Kyiv, , Ukraine

GSK Investigational Site, Kyiv, , Ukraine

GSK Investigational Site, Lviv, , Ukraine

GSK Investigational Site, Sumy, , Ukraine

GSK Investigational Site, Sympheropol, , Ukraine

GSK Investigational Site, Ternopil, , Ukraine

GSK Investigational Site, Uzhgorod, , Ukraine

GSK Investigational Site, Cambridge, Cambridgeshire, United Kingdom

GSK Investigational Site, Northwood, Middlesex, United Kingdom

GSK Investigational Site, Sutton, Surrey, United Kingdom

GSK Investigational Site, Aberdeen, , United Kingdom

GSK Investigational Site, Birmingham, , United Kingdom

GSK Investigational Site, Chelmsford, , United Kingdom

GSK Investigational Site, Leeds, , United Kingdom

GSK Investigational Site, London, , United Kingdom

GSK Investigational Site, London, , United Kingdom

GSK Investigational Site, Manchester, , United Kingdom

GSK Investigational Site, Oxford, , United Kingdom

GSK Investigational Site, Southampton, , United Kingdom

Contact Details

Name: GSK Clinical Trials

Affiliation: GlaxoSmithKline

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: