Spots Global Cancer Trial Database for Establishment and Characterization of Meningioma Patient-derived Organoids

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Trial Identification

Brief Title: Establishment and Characterization of Meningioma Patient-derived Organoids

Official Title: Establishment and Characterization of Meningioma Patient-derived Organoids

Study ID: NCT04478877

Conditions

Meningioma

Interventions

Study Description

Brief Summary: In this study, meningioma organoids will be established from patients' tissues and the characterization of the organoid will be performed.

Detailed Description: Aims and Hypothesis to be tested: The investigators hypothesized that the derived organoid should have a similar morphological and genetic mutation signatures to the patient primary tissue. Study period: 1 year for patient recruitment and organoid generation from patient tumor Study population: 30 Study samples: Patient's meningioma tumor sample are collected from patients with surgical needs. Sample collected are used for organoid culture. Morphological and genetic characteristics will be compared between the patient tumor sample and the corresponding derived organoids Primary outcome measures: Whole exome sequencing data of patient tumor tissue and patients-derived organoids