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Spots Global Cancer Trial Database for Safety and Efficacy of XmAb18087 ± Pembrolizumab in Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer

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Trial Identification

Brief Title: Safety and Efficacy of XmAb18087 ± Pembrolizumab in Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer

Official Title: A Phase 1b/2 Multiple-Dose Study to Evaluate the Safety and Efficacy of XmAb18087 ± Pembrolizumab in Subjects With Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer (DUET-1-02) Protocol

Study ID: NCT04590781

Study Description

Brief Summary: This is a Phase 1b/2, multiple-dose study designed to describe safety and efficacy, and to assess PK and immunogenicity of XmAb18087 monotherapy and in combination with pembrolizumab in participants with metastatic Merkel cell (MCC) or locoregional MCC that has recurred after locoregional therapy with surgery and/or radiation therapy, and mAb18087 monotherapy in participants with extensive-stage small cell lung cancer (SCLC) that has progressed after standard therapies. This study was terminated by the sponsor. No participants enrolled in Part B.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

City of Hope, Duarte, California, United States

USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Memorial Sloan Kettering, New York, New York, United States

OU Health, Stephenson Cancer Center, Oklahoma City, Oklahoma, United States

Swedish Cancer Institute, Seattle, Washington, United States

University of Washington, Seattle, Washington, United States

Contact Details

Name: Benjamin Thompson, MD, PhD

Affiliation: Medical Director, Clinical Development, Xencor

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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