Spots Global Cancer Trial Database for Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

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Trial Identification

Brief Title: Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

Official Title: Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

Study ID: NCT05100095

Conditions

Merkel Cell Carcinoma

Interventions

Radiation therapy

Study Description

Brief Summary: This study seeks to determine the safety and efficacy of shortening the primary and nodal adjuvant radiation therapy course from 2 Gy x 25 fractions to 3.6 Gy x 10 fractions in merkel cell carcinoma patients who may or may not be receiving immunotherapy.

Detailed Description: * To estimate the 2-year local control rate for adjuvant hypofractionated RT to the primary tumor bed. * To estimate the 2-year nodal control rate for adjuvant hypofractionated RT to the primary draining nodal basin. Secondary Objectives * To determine MCC disease outcomes including:time to non-nodal locoregional recurrence, time to nodal recurrence, time to distant mestasis, disease-free-survival and disease-specific survival for patients receiving hypofractionated adjuvant RT. * To assess acute and late RT associated toxicity within or neighboring the radiated field.