Spots Global Cancer Trial Database for Mesothelioma Avastin Plus Pemetrexed-cisplatin Study
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Trial Identification
Brief Title: Mesothelioma Avastin Plus Pemetrexed-cisplatin Study
Official Title: A Phase II-III Randomized Trial Pemetrexed-Cisplatin Chemotherapy With or Without Bevacizumab (Avastin), 15 mg/kg, for Malignant Pleural Mesothelioma (MPM)
Study ID: NCT00651456
Conditions
Study Description
Brief Summary: Our hypothesis is that the addition of bevacizumab to the standard chemotherapy treatment of MPM will improve overall survival and quality of life beyond that achieved with chemotherapy alone.
Detailed Description: A phase II trial associating the reference chemotherapy (pemetrexed plus cisplatin) with bevacizumab is needed to ensure that no specific toxicity is induced by this association, and that this triplet have interesting activity. As pleural mesothélioma is a rare tumor, a phase III trial, using the survival data from the phase II part study, will be able to include a sufficient number of patients, in a reasonable period of time, to answer the question of efficacy of the anti-angiogenic triplet, providing the efficacy outcomes could be considered as favorable, at the end of the phase II part of the study.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Centre Hospitalier du Pays d'Aix, Aix-en-Provence, , France
Annemasse - CH, Ambilly, , France
Amiens - CHU, Amiens, , France
Clinique de l'Europe, Amiens, , France
Angers - CHU, Angers, , France
Auxerre - CH, Auxerre, , France
CHU Besancon - Pneumologie, Besancon, , France
Bobigny - Hôpital Avicenne, Bobigny, , France
Bois-Guillaume - CHU, Bois-Guillaume, , France
Boujan sur Libron - Polyclinique Saint-Privat, Boujan sur Libron, , France
Hôpital Ambroise Paré - Pneumologie, Boulogne, , France
Brest - CHU, Brest, , France
Brest - HIA, Brest, , France
Béziers - CH, Béziers, , France
Caen - Centre François Baclesse, Caen, , France
CHU - Pneumologie, Caen, , France
Chauny - CH, Chauny, , France
Cherbourg - CH, Cherbourg, , France
Hôpital Percy-Armées - Pneumologie, Clamart, , France
CHU, Clermont-Ferrand, , France
Colmar - CH, Colmar, , France
Créteil - CHI, Créteil, , France
Denain - CH, Denain, , France
Centre Georges François Leclerc, Dijon, , France
CHU Hôpital du Bocage, Dijon, , France
Elbeuf - CH, Elbeuf, , France
Evreux - CH, Evreux, , France
Flers - CH, Flers, , France
CHU Grenoble - pneumologie, Grenoble, , France
Chartres - CH, Le Coudray, , France
Centre Hospitalier - Pneumologie, Le Havre, , France
Le Havre - HPE, Le Havre, , France
Centre Hospitalier - Pneumologie, Le Mans, , France
Le Mans - Clinique Victor Hugo, Le Mans, , France
CHU (Hôpital Calmette) - Pneumologie, Lille, , France
Limoges - Hôpital du Cluzeau, Limoges, , France
CH de Longjumeau, Longjumeau, , France
Lorient - CHBS, Lorient, , France
Centre Léon Bérard, Lyon, , France
HCL - Croix-Rousse, Lyon, , France
APHM - Hôpital Sainte Marguerite, Marseille, , France
Meaux - CH, Meaux, , France
Mont de Marsan - CH, Mont de Marsan, , France
Montpellier - CHRU, Montpellier, , France
Mulhouse - CH, Mulhouse, , France
CHU, Nancy, , France
Nantes - Centre René Gauducheau, Nantes, , France
Narbonne - Polyclinique Le Languedoc, Narbonne, , France
Nevers - CH, Nevers, , France
Nice - CAC, Nice, , France
Orléans - CH, Orléans, , France
Paray Le Monial - CH, Paray Le Monial, , France
Paray Le Monial - Clinique, Paray Le Monial, , France
Paris - Saint Louis, Paris, , France
APHP - Hopital Tenon - Pneumologie, Paris, , France
Paris - Curie, Paris, , France
Pau - CH, Pau, , France
HCL - Lyon Sud (Pneumologie), Pierre Bénite, , France
CHU, Poitiers, , France
Pontoise - CH, Pontoise, , France
Reims - CHU, Reims, , France
Rennes - CHU, Rennes, , France
Roubaix - CH, Roubaix, , France
Rouen - CHU, Rouen, , France
Saint Brieuc - CHG, Saint Brieuc, , France
Institut de Cancérologie de la Loire, Saint Priest en Jarez, , France
Saint Quentin - CH, Saint Quentin, , France
Saint-Malo - CH, Saint-Malo, , France
Centre Etienne Dolet, Saint-Nazaire, , France
Saint-Nazaire - CH, Saint-Nazaire, , France
Strasbourg - NHC, Strasbourg, , France
Suresnes - Hopital Foch, Suresnes, , France
Thonon les bains - CH, Thonon les bains, , France
Toulon - CHI, Toulon, , France
CHU Toulouse - Pneumologie, Toulouse, , France
Tours - CHU, Tours, , France
CH Valence, Valence, , France
Valenciennes - Clinique, Valenciennes, , France
CHI de la Haute-Saône - Pneumologie, Vesoul, , France
CH de Villefranche - Pneumologie, Villefranche, , France
Institut Gustave Roussy, Villejuif, , France
Contact Details
Name: Gilles Robinet, Dr
Affiliation: GFPC
Role: STUDY_DIRECTOR
Name: Arnaud Scherpereel, Dr
Affiliation: Intergroupe Francophone de Cancerologie Thoracique
Role: STUDY_DIRECTOR
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