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Spots Global Cancer Trial Database for Do Your Genes Put You at a Higher Risk of Developing Mesothelioma

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Trial Identification

Brief Title: Do Your Genes Put You at a Higher Risk of Developing Mesothelioma

Official Title: Consortium for the Sharing of Germ Line DNA and Tissue From Subjects With Mesothelioma

Study ID: NCT01590472

Conditions

Mesothelioma

Interventions

Study Description

Brief Summary: The purpose of this research study is to investigate the possibility that a person's genes put a person at a higher risk of developing mesothelioma. The investigators will examine genes from DNA (genetic material) isolated from blood. This study will also examine the impact of environmental and work exposures and family history of common cancers on the development of mesothelioma. The genetic markers in this study will basically identify how a person's body processes frequently encountered environmental pollutants and will not tell about chromosomes, specific diseases, or other potential health problems.

Detailed Description: Mesothelioma is a cancer that develops from serosal surfaces usually in response to prior asbestos exposure. A history of asbestos exposure can be elicited in more than 80% of mesothelioma victims. However, asbestos exposure alone is not sufficient to cause the development of mesothelioma. Nearly 27 million individuals in the US, were exposed to asbestos in the work place between 1940 and 1979 but just 3,000 new cases of mesothelioma are diagnosed each year. Therefore, the investigators hypothesis is that genetic variation in addition to asbestos exposure, and host factors contribute to the development of mesothelioma. It is estimated, based on the investigators preliminary studies, that a population in excess of 1,000 subjects with mesothelioma is required to perform a valid GWAS. Therefore a multicenter approach is necessary to collect data and DNA on sufficient numbers with mesothelioma to adequately evaluate genetic risk. It is the aim of this proposal to develop a consortium of mesothelioma investigators to share phenotypic data and DNA samples and to perform genome wide association scanning (GWAS).

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Johns Hopkins University, Baltimore, Maryland, United States

Mayo Clinic, Rochester, Minnesota, United States

New York University School of Medicine, New York, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

University of Pennsylvania, Philadelphia, Pennsylvania, United States

Contact Details

Name: Jill Ohar, MD

Affiliation: Wake Forest University

Role: STUDY_DIRECTOR

Name: Lee Krug, MD

Affiliation: Memorial Sloan Kettering Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Julie Brahmer, MD

Affiliation: Johns Hopkins University

Role: PRINCIPAL_INVESTIGATOR

Name: Harvey I Pass, MD

Affiliation: NYU Langone Health

Role: PRINCIPAL_INVESTIGATOR

Name: Tobias Peikert, MD

Affiliation: Mayo Clinic

Role: PRINCIPAL_INVESTIGATOR

Name: Daniel H Sterman, MD

Affiliation: University of Pennsylvania

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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