Spots Global Cancer Trial Database for Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients
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Trial Identification
Brief Title: Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients
Official Title: A Randomized Phase II Study Evaluating Efficacy and Safety of 2nd or 3rd Line Treatment by Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients
Study ID: NCT02716272
Conditions
Study Description
Brief Summary: The sponsor raise the hypothesis that inhibition of immune PD-1+/- CTLA-4 check-point(s) would delay tumor progression in patients with unresectable MPM, experiencing disease progression after one or two lines of chemotherapy including at least first-line with pemetrexed and platinum, without altering significantly the quality of life of patients.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Angers - CHU, Angers, , France
Avignon - Institut Sainte-Catherine, Avignon, , France
CHU, Clermont-Ferrand, , France
Dijon - CHU, Dijon, , France
Grenoble - CHU, Grenoble, , France
Centre Hospitalier - Pneumologie, Le Havre, , France
Centre Hospitalier - Pneumologie, Le Mans, , France
CHRU Lille - Hopital Calmette, Lille, , France
AP-HM Hôpital Nord, Marseille, , France
Mulhouse - CH, Mulhouse, , France
AP-HP Hopital Tenon - Pneumologie, Paris, , France
AP-HP Hôpital Bichat, Paris, , France
HCL Lyon Sud, Pierre Bénite, , France
Pontoise - CH, Pontoise, , France
Rennes - CHU, Rennes, , France
Rouen - CHU, Rouen, , France
Centre Etienne Dolet, Saint-Nazaire, , France
CHU Strasbourg, Strasbourg, , France
Toulon - CHI, Toulon, , France
Toulouse - CHU Larrey, Toulouse, , France
CHU Tours - Pneumologie, Tours, , France
Gustave Roussy, Villejuif, , France
Contact Details
Name: Arnaud Scherpereel, MD, PhD
Affiliation: Intergroupe Francophone de Cancerologie Thoracique
Role: PRINCIPAL_INVESTIGATOR
Name: Gérard Zalcman, MD, PhD
Affiliation: Intergroupe Francophone de Cancerologie Thoracique
Role: PRINCIPAL_INVESTIGATOR
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