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Brief Title: Genomic and Proteomic Profiling Targets Influenced Treatment in Metastatic Breast Cancer
Official Title: A Two Arm Pilot Study Utilizing Molecular Profiling to Find Potential Targets and Influence Treatments for Patients With Metastatic Breast Cancer or Advanced Gynecological Malignancies
Study ID: NCT02470819
Brief Summary: The primary objective is to examine the impact on progression-free survival of targeted therapy for breast cancer suggested by proteomic and genomic profiling.
Detailed Description: To explore the impact of targeted therapy for breast cancer suggested by proteomic and genomic profiling using RPMA, targeted resequencing, IHC analysis, WGS, RNA-seq, and Exome sequencing on progression-free survival. When a molecular target cannot be identified, the patient will be treated with a therapy selected on an empirical basis by the investigator/treating physician at the individual site and will be followed for survival status. Only available, FDA-approved agents will be used.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Name: Brian Leyland-Jones, MD
Affiliation: Avera McKennan
Role: PRINCIPAL_INVESTIGATOR