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Spots Global Cancer Trial Database for Study of ESR1 Mutations in Metastatic Breast Cancer

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Trial Identification

Brief Title: Study of ESR1 Mutations in Metastatic Breast Cancer

Official Title: Determination of ESR1 Mutations by Digital PCR During Aromatase Inhibitor Treatment in Metastatic Breast Cancer

Study ID: NCT02473120

Study Description

Brief Summary: The purpose of the study is to determine the frequency ESR1 mutations by Digital PCR in patient with metastatic breast cancer.

Detailed Description: Breast cancer is the most common cancer in woman. Aromatase inhibitors have demonstrated a real efficacy however a resistance to treatment exists. ESR1 mutations appear like involved in the mechanism of resistance to aromatase inhibitors treatment. The purpose of the study is to determine the frequency ESR1 mutations by Digital PCR in patient with metastatic breast cancer. The significance of the Digital PCR technique will be determined first in plasma issued from healthy volunteers. At the initiation of aromatase inhibitors treatment patient with metastatic breast cancer will be included in the study. During their follow-up visit every 3 months), their status towards their disease will be collected and a plasma will be collected too. When the patient progress clinically or radiologically the plasma concomitant to this progression will be analysed by Digital PCR to detect ESR1 mutations. The patient will be followed during 2 years.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: Yes

Locations

Centre Henri Becquerel, Rouen, , France

Contact Details

Name: Anne Perdrix, MD

Affiliation: Centre Henri Becquerel

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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