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Spots Global Cancer Trial Database for A Study of AC176 for the Treatment of Metastatic Castration Resistant Prostate Cancer

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Trial Identification

Brief Title: A Study of AC176 for the Treatment of Metastatic Castration Resistant Prostate Cancer

Official Title: A Phase I Study to Evaluate Safety, Tolerability, PK, Pharmacodynamics, and Preliminary Anti-Tumor Activity of AC176 in Patients With Metastatic Castration Resistant Prostate Cancer Who Have Progressed on at Least Two Prior Systemic Therapies

Study ID: NCT05241613

Interventions

AC176

Study Description

Brief Summary: This clinical trial is evaluating a drug called AC176 in participants with metastatic castration resistant prostate cancer (mCRPC) who have progressed on at least two prior systemic therapies. The main goals of this study are to: * Identify the recommended dose of AC176 that can be given safely to participants * Evaluate the side effects of AC176 * Evaluate pharmacokinetics of AC176 * Evaluate the effectiveness of AC176

Detailed Description: AC176-001 is a Phase I, first-in-human, open-label, multi-center dose-escalation study of AC176 given as a single agent. The AC176 is an investigational medicinal product that is a potent orally bioavailable Androgen Receptor (AR) degrader studied for the treatment of Metastatic Castration Resistant Prostate Cancer.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

Site 02, Denver, Colorado, United States

Site 03, Sarasota, Florida, United States

Site 05, Detroit, Michigan, United States

Site 01, Nashville, Tennessee, United States

Site 04, Dallas, Texas, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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