Spots Global Cancer Trial Database for A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency
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Trial Identification
Brief Title: A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency
Official Title: TRITON3: A Multicenter, Randomized, Open Label Phase 3 Study of Rucaparib Versus Physician's Choice of Therapy for Patients With Metastatic Castration Resistant Prostate Cancer Associated With Homologous Recombination Deficiency
Study ID: NCT02975934
Study Description
Brief Summary: The purpose of this study is to determine how participants with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib versus treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
University of Alabama at Birmingham, Birmingham, Alabama, United States
Mayo Clinic - Arizona, Phoenix, Arizona, United States
Arizona Oncology Associates - USOR, Tucson, Arizona, United States
University of Southern California, Beverly Hills, California, United States
Alliance Research Centers, Laguna Hills, California, United States
VA Greater Los Angeles Healthcare System, Los Angeles, California, United States
San Bernardino Urological Associates, San Bernardino, California, United States
Sharp Memorial Hospital, San Diego, California, United States
Pacific Hematology Oncology Associates, San Francisco, California, United States
San Francisco VA Health Care System, San Francisco, California, United States
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
St. Joseph Heritage Healthcare, Santa Rosa, California, United States
Kaiser Permanente, Northern CA, Vallejo, California, United States
Rocky Mountain Cancer Centers, Aurora, Colorado, United States
Yale University School of Medicine, New Haven, Connecticut, United States
Medical Oncology Hematology Consultants - USOR, Newark, Delaware, United States
Boca Raton Community Hospital, Inc., Boca Raton, Florida, United States
University of Florida Health Cancer Center, Orlando, Florida, United States
Atlanta Urological Group, Atlanta, Georgia, United States
Kaiser Permanente Medical Group, Honolulu, Hawaii, United States
Ochsner Medical Center, New Orleans, Louisiana, United States
University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, United States
Walter Reed National Military Medical Center, Bethesda, Maryland, United States
Maryland Oncology Hematology P.A., Columbia, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States
Henry Ford Hospital, Detroit, Michigan, United States
Minnesota Oncology Hematology, P.A., Minneapolis, Minnesota, United States
Minnesota Veterans Research Institute, Minneapolis, Minnesota, United States
University of Minnesota, Minneapolis, Minnesota, United States
Mayo Clinic - Rochester, MN, Rochester, Minnesota, United States
Alegent Health Bergan Mercy Hospital , GU Research Network, Omaha, Nebraska, United States
Nebraska Cancer Specialists, Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Premier Urology Associates, Lawrenceville, New Jersey, United States
Roswell Park, Buffalo, New York, United States
NYU Perlmutter Cancer Center, New York, New York, United States
Memorial Sloan Kettering CC, New York, New York, United States
Weill Cornell Medical College, New York, New York, United States
Premier Medical Group of the Hudson Valley PC, Poughkeepsie, New York, United States
University of Rochester, Rochester, New York, United States
SUNY Upstate Medical University, Syracuse, New York, United States
University of North Carolina Lineberger Cancer Center, Chapel Hill, North Carolina, United States
Carolina Urology Partners, Concord, North Carolina, United States
Durham VA Medical Center, Durham, North Carolina, United States
Oncology Hematology Care, Cincinnati, Ohio, United States
The Urology Group, Cincinnati, Ohio, United States
Kettering Medical Center, Kettering, Ohio, United States
Clinical Research Solutions, Middleburg Heights, Ohio, United States
VA Portland Health Care System, Portland, Oregon, United States
Northwest Cancer Specialist DBA Compass Oncology, Portland, Oregon, United States
Knight Cancer Institute, Portland, Oregon, United States
Urology Associates Clinical Research, Nashville, Tennessee, United States
Urology Clinics of North Texas, Dallas, Texas, United States
UT Southwestern Medical Center, Dallas, Texas, United States
UT Health Science Center, Houston, Texas, United States
Texas Oncology Cancer Center-Round Rock, Round Rock, Texas, United States
Urology of Virginia, Virginia Beach, Virginia, United States
MultiCare Regional Cancer Center - Gig Harbor, Gig Harbor, Washington, United States
VA Puget Sound HCS, Seattle, Washington, United States
University of Washington Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Southside Cancer Care Centre, Miranda, New South Wales, Australia
Orange Health Service, Orange, New South Wales, Australia
Northern Cancer Insitute, St. Leonards, Saint Leonards, New South Wales, Australia
St John of God Hospital, Subiaco, Subiaco, Western Australia, Australia
Peninsula & Southeast Oncology, Frankston, , Australia
Barwon Health, University Hospital Geelong, Geelong, , Australia
Royal Hobart Hospital, Hobart, , Australia
Riverina Cancer Care Centre, Wagga Wagga, , Australia
ZNA Middelheim, Antwerp, , Belgium
AZ Groeninge, Kortrijk, , Belgium
CHU Sart-Tilman, Liège, , Belgium
Clinique et Maternité Sainte-Elisabeth, Namur, , Belgium
Tom Baker Cancer Centre, Calgary, Alberta, Canada
Cancer Care Manitoba, Winnipeg, Manitoba, Canada
Centre Hospitalier Universitaire Dr-Georges-L.-Dumont, Moncton, New Brunswick, Canada
London Health Sciences Centre, London, Ontario, Canada
The Ottawa Hospital, Ottawa, Ontario, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Lakeridge Health Medical Specialty Medical Oncology, Oshawa, , Canada
Sunnybrook Odette Cancer Centre, Toronto, , Canada
Copenhagen University Hospital, Copenhagen, , Denmark
Herlev Hospital, Herlev, , Denmark
Vejle Sygehus, Vejle, , Denmark
Centre Georges François Leclerc, Dijon, , France
Clinique Victor Hugo Centre Jean Bernard, Le Mans, , France
Hôpital Privé La Louvière, Lille, , France
Centre Léon Bérard, Lyon, , France
Polyclinique de Gentilly (Centre D'Oncologie De Gentilly), Nancy, , France
Institut Curie, Paris, , France
Centre Armoricain de Radiotherapie, Imagerie medicale et Oncologie, CARIO, Plérin, , France
CRLCC Eugene Marquis, Rennes, , France
Institut Gustave-Roussy, Villejuif, , France
Gemeinschaftspraxis für Hämatologie&Onkologie, Augsburg, , Germany
Charite - Universitaetsmedizin Berlin, Berlin, , Germany
Apotheke des Städtischen Klinikums Braunschweig, Braunschweig, , Germany
University Hospital Carl Gustav Carus, Dresden, , Germany
Universitatsklinikum Dusseldorf, Dusseldorf, , Germany
Urologische Gemeinschaftspraxis, Emmendingen, , Germany
Universitaetsklinikum Hamburg-Eppendorf (UKE), Hamburg, , Germany
Universitatsklinikum Jena, Jena, , Germany
Universitätsklinikum Köln, Köln, , Germany
Universitätsklinikum Schleswig-Holstein, Lubeck, , Germany
Medizinischen Fakultät Mannheim der Universität Heidelberg, Mannheim, , Germany
Studienpraxis Urologie, Nurtingen, , Germany
University of Tuebingen, Tuebingen, , Germany
Die GesundheitsUnion (DGU), Wuppertal, , Germany
Cork University Hospital, Cork, , Ireland
Adelaide & Meath Hospital, Incorporating the National Children's Hospital, Dublin, , Ireland
Mater Misericordiae University Hospital, Dublin, , Ireland
Mater Private Hospital (MPH), Dublin, , Ireland
St James's Hospital, Dublin, , Ireland
St. Vincent's University Hospital, Dublin, , Ireland
Rambam Health Care Campus (RHCC), Rambam Medical Center, Haifa, , Israel
Hadassah University Hospital, Jerusalem, , Israel
Meir Medical Center, Kfar Saba, , Israel
Rabin Medical Center-Beilinson Campus, Petach Tikva, , Israel
The Tel Aviv Sourasky Medical Center (Ichilov Hospital), Tel Aviv, , Israel
Chaim Sheba Medical Center, Tel Hashomer, , Israel
Ospedale San Donato, Azienda USLSUDEST, Arezzo, , Italy
Ospedale Santa Maria delle Croci, Faenza, , Italy
Romagnolo per lo Studio e la Cura dei Tumori IRST-IRCCS - Oncologia medica, Meldola, , Italy
IEO Instituto Europeo di Oncologia, Milano, , Italy
University of Modena and Reggio Emilia, Modena, , Italy
Azienda Ospedaliera San Camillo-Forlanini, Roma, , Italy
Azienda Opsedaliera S. Maria di Terni, Terni, , Italy
Presidio Ospedaliero Santa Chiara di Trento, Trento, , Italy
Hospital Universitari Germans Trias i Pujol, Barcelona, , Spain
Hospital Universitario Reina Sofia, Córdoba, , Spain
Hospital General Universitario de Guadalajara, Guadalajara, , Spain
Hospital Universitario Lucus Augusti., Lugo, , Spain
MD Anderson Cancer Center - Madrid, Madrid, , Spain
Hospital Universitario Ramón y Cajal, Madrid, , Spain
Hospital 12 de Octubre, Madrid, , Spain
Hospital Universitario La Paz, Madrid, , Spain
Hospital Clinico Universitario Virgen de la Victoria, Málaga, , Spain
Hospital Universitario Central de Asturias, Oviedo, , Spain
Corporacio Sanitaria Parc Tauli, Sabadell, , Spain
Marques de Valdecilla University Hospital (HUMV), Santander, , Spain
Hospital Universitario Virgen del Rocío, Sevilla, , Spain
Instituto Valenciano de Oncología, Valencia, , Spain
Guy's and St Thomas' NHS Foundation Trust, London, England, United Kingdom
Royal Marsden Hospital, London, England, United Kingdom
Oxford Cancer Centre, Medical Oncology Unit, Oxford, England, United Kingdom
Royal Preston Hospital, Preston, England, United Kingdom
Wexham Park Hospital, Slough, England, United Kingdom
Velindre Hospital, Cardiff, , United Kingdom
Royal Marsden Hospital, London, , United Kingdom
Musgrove Park Hospital, Taunton, , United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, , United Kingdom
Contact Details
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