Spots Global Cancer Trial Database for Study of Abiraterone Acetate in Subjects With Metastatic Castration Resistant Prostate Cancer
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Trial Identification
Brief Title: Study of Abiraterone Acetate in Subjects With Metastatic Castration Resistant Prostate Cancer
Official Title: A Randomised, Double-Blind, Multicentre Phase Ⅲ Study to Evaluate Abiraterone Acetate Versus Placebo Combined With Prednisone in Subjects With Asymptomatic or Mild Symptoms Without Chemotherapy, Metastatic Castration Resistant Prostate Cancer.
Study ID: NCT04056754
Study Description
Brief Summary: Abiraterone acetate is an orally effective CYP17 inhibitor, which is metabolized into abiraterone in the body, and its inhibitory activity against CYP17 is 10-30 times that of ketoconazole. Clinical studies have shown that abiraterone acetate can significantly reduce the level of prostate specific antigen (PSA) in PCa patients, and help to reduce tumors, extending the lifespan of patients with advanced PCa for several years, and the toxicity is acceptable.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
Peking Union Medical College Hospital, Beijing, Beijing, China
Peking University First Hospital, Beijing, Beijing, China
Chongqing Cancer Hospital, Chongqing, Chongqing, China
Sun-Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Harbin Medical University Cancer Hospital, Ha'erbin, Heilongjiang, China
Henan Cancer Hospital, Zhengzhou, Henan, China
Guangzhou Military Region Wuhan General Hospital, Wuhan, Hubei, China
TongJi medical college of HuaZhong University of Science & Technology Affiliated TongJi Hospital, Wuhan, Hubei, China
Jiangsu Province Hospital, Nanjing, Jiangsu, China
Qilu Hospital of Shandong University, Jinan, Shandong, China
Fudan University Medical College Affiliated Huadong Hospital, Shanghai, Shanghai, China
Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China
RenJi Hospital of Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China
West China Hospital，Sichuan University, Chengdu, Sichuan, China
The Second Affiliated Hospital of Zhenjiang University School of Medicine, Hangzhou, Zhejiang, China
Contact Details
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