Spots Global Cancer Trial Database for A Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy as First-line Treatment in Subjects With RAS/BRAF Wild Metastatic Colorectal Cancer
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Trial Identification
Brief Title: A Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy as First-line Treatment in Subjects With RAS/BRAF Wild Metastatic Colorectal Cancer
Official Title: A Randomized, Open-label, Parallel Controlled, Multi-center Phase III Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy as First-line Treatment in Subjects With RAS/BRAF Wild Metastatic Colorectal Cancer
Study ID: NCT04854668
Conditions
Study Description
Brief Summary: This is an open label, randomized, phase Ⅲ study to treat subjects with RAS/BRAF wild-type, unresectable metastatic colorectal cancer. The patients will be randomized into two arms consist of Anlotinib (3 weeks/cycle) + CapeOx and Bevacizumab (3 week/cycle) + CapeOx at a ratio of 1:1. This study is conducted to assess the efficacy and safety of Anlotinib and Chemotherapy as first-line treatment in subjects with RAS/BRAF wild-type Metastatic Colorectal Cancer.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The People's Hospital of Chizhou, Chizhou, Anhui, China
Fujian Medical University Union Hospital, Fuzhou, Anhui, China
Anhui Provincial Hospital, Hefei, Anhui, China
Anhui Cancer Hospital, Hefei, Anhui, China
Xuancheng People's Hospital, Xuancheng, Anhui, China
China-Japan Friendship Hospital, Beijing, Beijing, China
Peking University Frist Hospital, Beijing, Beijing, China
Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing, China
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China
Fuling Hospital Affiliated to Chongqing University, Chongqing, Chongqing, China
Fujian Cancer Hospital, Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China
Gansu Provincial Hospital, Lanzhou, Gansu, China
Lanzhou University Second Hospital, Lanzhou, Gansu, China
The First Hospital of Lanzhou University, Lanzhou, Gansu, China
The First Affiliated Hospital Of Guangzhou Medical University, Guangzhou, Guangdong, China
Qingyuan People's Hospital, Qingyuan, Guangdong, China
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Liuzhou Workers' Hospital, Liuzhou, Guangxi, China
The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China
Guizhou Provincial People's Hospital, Guiyang, Guizhou, China
The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China
Tangshan People's Hospital, Tangshan, Hebei, China
The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China
Harbin Medical University Affiliated Cancer Hospital, Harbin, Heilongjiang, China
The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Huaihe Hospital of Henan University, Kaifeng, Henan, China
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China
Nanyang Second General Hospital, Nanyang, Henan, China
Xinyang Central Hospital, Xinyang, Henan, China
Henan Cancer Hospital, Zhengzhou, Henan, China
The First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, China
Tongji Hospital Affiliated to Tongji Medical College Hust, Wuhan, Hubei, China
Hubei Cancer Hospital, Wuhan, Hubei, China
Xiangyang Central Hospital, Xiangyang, Hubei, China
Hunan Cancer Hospital, Changsha, Hunan, China
Affiliated Hospital of Chifeng University, Chifeng, Inner Mongolia, China
Chifeng Municipal hospital, Chifeng, Inner Mongolia, China
The First Peoples Hospital of Changzhou, Changzhou, Jiangsu, China
Jiangsu Cancer hospital, Nanjing, Jiangsu, China
Zhongda Hospital Southeast University, Nanjing, Jiangsu, China
Nanjing First Hospital, Nanjing, Jiangsu, China
Nanjing Hospital of C.M., Nanjing, Jiangsu, China
Jiangsu Province People's Hospital, Nanjing, Jiangsu, China
Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
Taizhou Second People's Hospital, Taizhou, Jiangsu, China
Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China
Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
JiangXi PingXiang People's Hospital, Pingxiang, Jiangxi, China
Jilin Province FAW General Hospital, Changchun, Jilin, China
Jilin Cancer Hospital, Changchun, Jilin, China
Meihekou Central Hospital, Meihekou, Jilin, China
Yanbian University Hospital, Yanji, Jilin, China
The First Affiliatde Hospital of DaLin Medical University, Dalian, Liaoning, China
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China
Genertec Liaoyou Gem Flower Hospital, Panjin, Liaoning, China
Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Liaoning Cancer Hospital, Shenyang, Liaoning, China
The First Hospital of China Medical University, Shenyang, Liaoning, China
Inner Mongolia Autonomous Region Cancer Hospital, Hohhot, Neimenggu, China
Qinghai University Affiliated Hospital, Xining, Qinghai, China
3201 Hospital, Hanzhong, Shaanxi, China
Hanzhong Central Hospital, Hanzhong, Shaanxi, China
Xi'an International Medical Center Hospital, Xi'an, Shaanxi, China
Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
The Second Affiliated Hospital of PLA Air Force Military Medical University, Xi'an, Shaanxi, China
Shandong Cancer Hospital Affiliated to Shandong Univercity, Jinan, Shandong, China
Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Liaocheng People's Hospital, Liaocheng, Shandong, China
Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong, China
Yantai Yuhuangding Hospital, Yantai, Shandong, China
Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China
Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai, China
Shanghai Tenth People's Hospital, Shanghai, Shanghai, China
Shanghai General Hospital, Shanghai, Shanghai, China
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China
Changzhi People's Hospital, Changzhi, Shanxi, China
Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi, China
Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin, China
Peking University BinHai Hospital, Tianjin, Tianjin, China
The First People's Hospital of Kashgar, Kashgar, Xinjiang, China
Affiliated Tumor Hospital of Xinjiang Medical University, Ürümqi, Xinjiang, China
First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang, China
Yunnan Cancer Hospital, Kunming, Yunnan, China
The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Huzhou Cancer Hospital, Huzhou, Zhejiang, China
Contact Details
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