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Spots Global Cancer Trial Database for A Clinical-biological Prospective Cohort of Patients With BRAFV600E-mutated Metastatic Colorectal Cancer

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Trial Identification

Brief Title: A Clinical-biological Prospective Cohort of Patients With BRAFV600E-mutated Metastatic Colorectal Cancer

Official Title: A Study to Collect Patients, Medical, and Biological Data From Patients Being Treated for Metastatic Colorectal Cancer With a Specific Genetic Mutation: BRAFV600E

Study ID: NCT05639413

Study Description

Brief Summary: The study will be conducted in patients with metastatic colorectal cancer (mCRC) harboring a BRAFV600E mutation, to collect clinical data and biological samples to be used for research but also to gather real-world clinical data concerning the treatments and the survival outcomes in patients with this pathology.

Detailed Description: Despite substantial progress made in the first- and second line mCRC settings, there are still unmet clinical needs for patients harboring BRAFV600E mutations, especially those with microsatellite stability (MSS) / proficient mismatch repair (pMMR) tumor. The overall survival and access to different treatment in the real-life setting are unknown. Moreover, patient prognosis remains poor and therapeutic resistance to combinations with BRAF inhibitors, is at present, nearly universal. Therefore, it seems essential to prospectively collect clinical and biological data about this rare mCRC subtype. These data will allow us to improve knowledge and to identify clinical and biological factors that could drive therapeutic decisions, predict resistance to treatments, and that are prognostic for survival. In this context, we designed this large, prospective, cohort study to collect clinical data and biological samples to be used for research but also to gather real-world clinical data concerning the treatments and the survival outcomes in patients with BRAFV600E mCRC. This collection of clinical and biological data (tumor tissue and blood samples) will allow us to identify predictive and prognostic biomarkers with several research work packages planned: i. To evaluate the circulating tumor DNA (ctDNA) during the metastatic first-, second-, and third-line treatment to: * Evaluate its positive and negative predictive value. * Identify molecular alterations preceding and explaining clinical resistance during BRAF/EGFR inhibition therapy and immunotherapy. ii. To evaluate BRAFV600E mCRC immune environment both at the tumor and blood level (immunomonitoring). iii. To study specific the dMMR/MSI BRAFV600E subgroup. Furthermore, the data collected will describe the therapeutic management of BRAFV600E mCRC patients in the routine-practice setting which will bring very useful data. The results of the COBRAF study could lay the groundwork to better understand BRAFV600E mCRC and to identify prognostic and predictive biomarkers helping the development of new therapeutic approaches in this population.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Centre Hospitalier D'Avignon, Avignon, , France

Centre Hospitalier de Bayeux, Bayeux, , France

Institut Bergonie, Bordeaux, , France

Ch de Cahors, Cahors, , France

Infirmerie Protestante de Lyon, Caluire-et-Cuire, , France

Chu Estaing de Clermont-Ferrand, Clermont-Ferrand, , France

Aphp - Hopital Henri Mondor, Créteil, , France

Groupe Hospitalier Mutualiste de Grenoble, Grenoble, , France

Chu de Grenoble Alpes - Hopital Michallon, La Tronche, , France

Groupe Hospitalier Emile Roux, Le Puy-en-Velay, , France

Hopital Franco-Britannique, Levallois-Perret, , France

Chu Dupuytren, Limoges, , France

Centre Leon Berard, Lyon, , France

Intitut Paoli Calmettes, Marseille, , France

Grand Hopital de L'Est Francilien - Site de Meaux, Meaux, , France

Centre Antoine Lacassagne, Nice, , France

Aphp - Hopital Saint Louis, Paris, , France

Hopital Saint Antoine, Paris, , France

Aphp - Hopital Bichat, Paris, , France

Aphp - La Pitie Salpetriere, Paris, , France

Institut Mutualiste Montsouris, Paris, , France

Gh Diaconesses Croix Saint Simon, Paris, , France

Ch Perpignan, Perpignan, , France

Chu Poitiers, Poitiers, , France

Chu de Reims, Reims, , France

Chu Rennes Pontchaillou, Rennes, , France

Chu de Rouen, Rouen, , France

Ch de Saint Malo, Saint-Malo, , France

ICANS, Strasbourg, , France

Chu de Tours, Tours, , France

Chru de Nancy, Vandœuvre-lès-Nancy, , France

Contact Details

Name: Christelle DE LA FOUCHARDIERE, MD

Affiliation: CENTRE LEON BERARD - LYON

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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