Spots Global Cancer Trial Database for Chemotherapy and Avastin Followed by Maintenance Treatment With Avastin +/- Tarceva
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Trial Identification
Brief Title: Chemotherapy and Avastin Followed by Maintenance Treatment With Avastin +/- Tarceva
Official Title: Avastin and Chemotherapy Followed by Avastin Alone or in Combination With Tarceva for the Treatment of Metastatic Colorectal Cancer.
Study ID: NCT00598156
Conditions
Study Description
Brief Summary: Chemotherapy and bevacizumab is given for 4 months. Patients who have not progressed will continue with maintenance treatment with either bevacizumab (Avastin) alone, or bevacizumab and erlotinib (Tarceva).
Detailed Description: Patients with metastatic colorectal cancer will be treated with standard chemotherapy according to the investigators choice. In addition to chemotherapy, Avastin (bevacizumab) will be given during the treatment period. After the chemotherapy is finished (after 18 weeks), maintenance therapy will be given and the patients will be randomized to treatment with either with Avastin alone or Avastin in combination with Tarceva (erlotinib). Patients with progressive disease, or patients suitable to curative resection of metastases will be taken out of study.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Vejle Hospital, Department of Oncology, Copenhagen, , Denmark
Esbjerg Hospital, Esbjerg, , Denmark
Herning Hospital, Herning, , Denmark
Hillerod Hospital, Department of Oncology, Hillerod, , Denmark
Odense Hospital, Department of Oncology, Odense, , Denmark
Roskilde Hospital, Department of Oncology, Roskilde, , Denmark
Ryhov Hospital, Department of Oncology, Jonkoping, , Sweden
Kalmar Hospital, Department of Oncology, Kalmar, , Sweden
Lund University Hospital, Department of Oncology, Lund, , Sweden
University Hospital MAS, Malmo, , Sweden
Karolinska University Hospital, Department of Oncology, Stockholm, , Sweden
Sundsvall Hospital, Department of Oncology, Sundsvall, , Sweden
University Hospital of Norrland, Department of Oncology, Umeå, , Sweden
Akademiska Hospital, Department of Oncology, Uppsala, , Sweden
Vaxjo Hospital, Department of Oncology, Vaxjo, , Sweden
Contact Details
Name: Anders Johnsson, MD PhD
Affiliation: Lund University Hospital, Sweden
Role: PRINCIPAL_INVESTIGATOR
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