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Brief Title: FLOX + Cetuximab (Erbitux®) for Patients With Metastatic Colorectal Cancer and Wild Type K-RAS Tumor
Official Title: FLOX + Cetuximab (Erbitux®): First Line Treatment for Patients With Metastatic Colorectal Cancer and Wild Type K-RAS Tumor, A Phase II Study
Study ID: NCT00660582
Brief Summary: The Nordic FLOX-regime consists of a combination of bolus 5-FU, leukovorin and oxaliplatin (Eloxatin®). Cetuximab (Erbitux®) is an antibody against the epidermal growth factor receptor (EGFR). The combination of FLOX and weekly Erbitux has been investigated in the Nordic VII study where 571 patients were randomized to FLOX (regime A) or FLOX + Erbitux (regime B or C). Effect-data has not yet been published but the combination is well tolerated, and other studies have shown that Erbitux administered with chemotherapy seem to be more efficient than chemotherapy alone. The main purpose with this study is to investigate the effect of FLOX and Erbitux given every second week as first line treatment for patients with metastatic colorectal cancer and K-RAS wildtype tumor. The latest accessible data regarding treatment towards EGFR and K-RAS mutations shows that patients with K-RAS wildtype responds better to treatment than patients with K-RAS mutations.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Department of Oncology, Aalborg University Hospital, Aalborg, , Denmark
Department of Oncology, Herlev University Hospital, Herlev, , Denmark
Department of Oncology, Odense University Hospital, Odense, , Denmark
Department of Oncology, Haukeland University Hospital, Bergen, , Norway
Kreftsenteret, Ullevaal University Hospital, Oslo, , Norway
Section of Oncology, Uppsala University Hospital, Uppsala, , Sweden
Name: Per Pfeiffer, MD
Affiliation: Odense University Hospital
Role: PRINCIPAL_INVESTIGATOR