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Brief Title: Regorafenib With Low-dose Chemotherapies and Aspirin Followed by Standard Chemotherapies in Metastatic Colorectal Cancer
Official Title: Induction Regorafenib in Combination With Metronomic Cyclophosphamide, Capecitabine, and Low-dose Aspirin Followed by Chemotherapy in Second Line Metastatic Colorectal Cancer Carcinoma An Open-label Randomized Phase II-III Study
Study ID: NCT05462613
Brief Summary: This study evaluates the interest of regorafenib in combination of metronomic chemotherapies and low-dose aspirin as a 2 months induction therapy before chemotherapy initiation in the second-line metastatic colorectal carcinoma
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CHU de Besançon, Besançon, , France
Hôpital Henri Mondor, Créteil, , France
Centre Georges François Leclerc, Dijon, , France
Centre Léon Bérard, Lyon, , France
Hôpital Privé Jean Mermoz, Lyon, , France
Hôpital Nord Franche Comté, Montbeliard, , France
Groupe hospitalier de la région de Mulhouse et Sud Alsace, Mulhouse, , France
Hôpital Européen Georges Pompidou, Paris, , France
Hôpital la Pitié-Salpétrière, Paris, , France
Hôpital Saint antoine, Paris, , France
Institut Mutualiste Montsouris, Paris, , France
CHU de Reims - Hôpital Robert Debré, Reims, , France
Hôpital FOCH, Suresnes, , France