Spots Global Cancer Trial Database for GFRα4 CAR T Cells in MTC Patients
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Trial Identification
Brief Title: GFRα4 CAR T Cells in MTC Patients
Official Title: Phase I Trial of GFRα4 CAR T Cells in Adult Patients With Recurrent or Metastatic Medullary Thyroid Cancer
Study ID: NCT04877613
Conditions
Study Description
Brief Summary: This is an open-label phase 1 study to assess the safety and feasibility of autologous T cells expressing a single-chain scFv targeting GFRα4 with tandem TCR/CD3ζ and 4-1BB (TCRζ/4-1BB) co-stimulatory domains (referred to as "CART-GFRa4 cells") in patients with incurable medullary thyroid cancer (MTC).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Contact Details
Name: Roger Cohen, MD
Affiliation: University of Pennsylvania
Role: PRINCIPAL_INVESTIGATOR
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