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Brief Title: Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma
Official Title: A Randomized Phase 2 Trial of Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma
Study ID: NCT03646617
Brief Summary: The main purpose of this study is to determine the safety of combining ipilimumab and nivolumab with hypofractionated radiotherapy to a single tumor in patients with metastatic melanoma. Another purpose of this study is to determine the effect of ipilimumab, nivolumab and hypofractionated radiotherapy on the cancer as compared to ipilimumab and nivolumab.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Lancaster General Hospital, Lancaster, Pennsylvania, United States
Abramson Cancer Center, Philadelphia, Pennsylvania, United States
Huntsman Cancer Institute at the University of Utah, Salt Lake City, Utah, United States
Name: Tara Mitchell, MD
Affiliation: Abramson Cancer Center
Role: PRINCIPAL_INVESTIGATOR