Spots Global Cancer Trial Database for AMG510 (Sotorasib) Plus Lenvatinib as Second-line Treatment in Patients With KRASG12C Mutant, Metastatic NSCLC
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Trial Identification
Brief Title: AMG510 (Sotorasib) Plus Lenvatinib as Second-line Treatment in Patients With KRASG12C Mutant, Metastatic NSCLC
Official Title: A Multicentre, Single-arm Phase II Trial of Sotorasib Plus Lenvatinib, as Second-line Treatment in Patients With KRASG12C-mutant, Metastatic NSCLC
Study ID: NCT06068153
Study Description
Brief Summary: AMBER is a multicentre, single-arm phase II trial. The protocol treatment consists of of sotorasib plus lenvatinib, as a second-line treatment. The primary objective of the trial is to evaluate the clinical efficacy of sotorasib plus lenvatinib, in terms of objective response rate, for patients with KRASG12C-mutant, metastatic NSCLC.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Medical University of Innsbruck / UK für Innere Medizin V, Innsbruck, , Austria
University Hospital of Munich (LMU), Department of Medicine V (Pneumology/Thoracic Oncology), Munich, , Germany
Alicante University Dr Balmis Hospital ISABIAL, Alicante, , Spain
Ico Badalona - Hospital Germans Trias I Pujol, Badalona, , Spain
Hospital Universitario Lucus Augusti, Lugo, , Spain
Hospital Universitario de Salamanca, Salamanca, , Spain
Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz De Tenerife, , Spain
Hospital Universitario Virgen Del Rocio, Sevilla, , Spain
Hospital Universitario de Toledo, Toledo, , Spain
Hospital Universitario Y Politécnico La Fe, Valencia, , Spain
Istituto Oncologico della Svizzera Italiana, Bellinzona, , Switzerland
Kantonsspital Graubünden, Chur, , Switzerland
HFR Fribourg, Fribourg, , Switzerland
HUG, Geneva, , Switzerland
Kantonsspital Winterthur, Winterthur, , Switzerland
Contact Details
Name: Alfredo Addeo
Affiliation: Département d'Oncologie Hôpitaux Universitaires de Genève
Role: STUDY_CHAIR
Name: Sanjay Popat
Affiliation: Royal Marsden NHS Foundation Trust
Role: STUDY_CHAIR
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