Spots Global Cancer Trial Database for A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
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Trial Identification
Brief Title: A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
Official Title: A Phase III, Two-Arm, Parallel, Randomized, Multi-Center, Open-Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients With Metastatic Non-Small Cell Lung Cancer (mNSCLC).
Study ID: NCT05984277
Conditions
Study Description
Brief Summary: The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%.
Detailed Description: Adult patients with a histologically or cytologically documented metastatic NSCLC, with tumors that lack activating EGFR, ALK, and ROS1 alterations are eligible for enrollment. Patients will be randomized in a 1:1 ratio to receive treatment with volrustomig + chemotherapy or pembrolizumab + chemotherapy. Tumor evaluation scans will be performed until disease progression as efficacy assessment. All patients will be followed for survival until the end of the study. An data monitoring committee (DMC) composed of independent experts will be convened to confirm the safety and tolerability of the proposed dose and schedule.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Prescott, Arizona, United States
Research Site, Hot Springs National Park, Arkansas, United States
Research Site, Springdale, Arkansas, United States
Research Site, Palo Alto, California, United States
Research Site, Denver, Colorado, United States
Research Site, Denver, Colorado, United States
Research Site, Newark, Delaware, United States
Research Site, Fort Myers, Florida, United States
Research Site, Orlando, Florida, United States
Research Site, Saint Petersburg, Florida, United States
Research Site, Tallahassee, Florida, United States
Research Site, West Palm Beach, Florida, United States
Research Site, Indianapolis, Indiana, United States
Research Site, Des Moines, Iowa, United States
Research Site, Louisville, Kentucky, United States
Research Site, Baton Rouge, Louisiana, United States
Research Site, Marrero, Louisiana, United States
Research Site, Annapolis, Maryland, United States
Research Site, Baltimore, Maryland, United States
Research Site, Baltimore, Maryland, United States
Research Site, Silver Spring, Maryland, United States
Research Site, Towson, Maryland, United States
Research Site, Detroit, Michigan, United States
Research Site, Hattiesburg, Mississippi, United States
Research Site, Grand Island, Nebraska, United States
Research Site, Omaha, Nebraska, United States
Research Site, Belleville, New Jersey, United States
Research Site, Albany, New York, United States
Research Site, East Syracuse, New York, United States
Research Site, Fresh Meadows, New York, United States
Research Site, Westbury, New York, United States
Research Site, Cleveland, Ohio, United States
Research Site, Columbus, Ohio, United States
Research Site, Columbus, Ohio, United States
Research Site, Dayton, Ohio, United States
Research Site, Portland, Oregon, United States
Research Site, Pittsburgh, Pennsylvania, United States
Research Site, Memphis, Tennessee, United States
Research Site, Nashville, Tennessee, United States
Research Site, Nashville, Tennessee, United States
Research Site, Houston, Texas, United States
Research Site, Lancaster, Texas, United States
Research Site, Fairfax, Virginia, United States
Research Site, Henrico, Virginia, United States
Research Site, Tacoma, Washington, United States
Research Site, Buenos Aires, , Argentina
Research Site, Caba, , Argentina
Research Site, Caba, , Argentina
Research Site, Caba, , Argentina
Research Site, Ciudad de Córdoba, , Argentina
Research Site, Córdoba, , Argentina
Research Site, La Plata, , Argentina
Research Site, La Plata, , Argentina
Research Site, Rosario, , Argentina
Research Site, Clayton, , Australia
Research Site, Fitzroy, , Australia
Research Site, Heidelberg, , Australia
Research Site, South Brisbane, , Australia
Research Site, Sydney, , Australia
Research Site, Linz, , Austria
Research Site, Wels, , Austria
Research Site, Aalst, , Belgium
Research Site, Antwerpen, , Belgium
Research Site, Gent, , Belgium
Research Site, Barretos, , Brazil
Research Site, Curitiba, , Brazil
Research Site, Florianópolis, , Brazil
Research Site, Fortaleza, , Brazil
Research Site, Natal, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Rio De Janeiro, , Brazil
Research Site, Santa Cruz do Sul, , Brazil
Research Site, Sao Paulo, , Brazil
Research Site, Calgary, Alberta, Canada
Research Site, Edmonton, Alberta, Canada
Research Site, Winnipeg, Manitoba, Canada
Research Site, Halifax, Nova Scotia, Canada
Research Site, Barrie, Ontario, Canada
Research Site, Oshawa, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Levis, Quebec, Canada
Research Site, Trois-Rivières, Quebec, Canada
Research Site, Chicoutimi, , Canada
Research Site, Chengdu, , China
Research Site, Chengdu, , China
Research Site, Olomouc, , Czechia
Research Site, Ostrava - Vitkovice, , Czechia
Research Site, Praha 2, , Czechia
Research Site, Praha, , Czechia
Research Site, Angers, , France
Research Site, Avignon, , France
Research Site, Bayonne, , France
Research Site, Bordeaux, , France
Research Site, Caen, , France
Research Site, Lille, , France
Research Site, Limoges, , France
Research Site, Marseille, , France
Research Site, Montpellier, , France
Research Site, Paris Cedex 5, , France
Research Site, Quimper cedex, , France
Research Site, Reims, , France
Research Site, Saint-Malo, , France
Research Site, Strasbourg Cedex, , France
Research Site, Suresnes, , France
Research Site, Berlin-Zehlendorf, , Germany
Research Site, Bonn, , Germany
Research Site, Dresden, , Germany
Research Site, Essen, , Germany
Research Site, Gauting, , Germany
Research Site, Georgsmarienhuette, , Germany
Research Site, Halle, , Germany
Research Site, Hamburg, , Germany
Research Site, Heidelberg, , Germany
Research Site, Immenhausen, , Germany
Research Site, Koblenz, , Germany
Research Site, Nürnberg, , Germany
Research Site, Tuebingen, , Germany
Research Site, Budapest, , Hungary
Research Site, Budapest, , Hungary
Research Site, Budapest, , Hungary
Research Site, Gyöngyös - Mátraháza, , Hungary
Research Site, Győr, , Hungary
Research Site, Pécs, , Hungary
Research Site, Szekszárd, , Hungary
Research Site, Székesfehérvár, , Hungary
Research Site, Törökbálint, , Hungary
Research Site, Bengaluru, , India
Research Site, Delhi, , India
Research Site, Hyderabad, , India
Research Site, Kolkata, , India
Research Site, Kolkata, , India
Research Site, Mysuru, , India
Research Site, Nagpur, , India
Research Site, Nashik, , India
Research Site, New Delhi, , India
Research Site, Varanasi, , India
Research Site, Bari, , Italy
Research Site, Bergamo, , Italy
Research Site, Catanzaro, , Italy
Research Site, Milano, , Italy
Research Site, Padova, , Italy
Research Site, Parma, , Italy
Research Site, Pavia, , Italy
Research Site, Ravenna, , Italy
Research Site, Roma, , Italy
Research Site, Roma, , Italy
Research Site, Fukuoka-shi, , Japan
Research Site, Kashiwa, , Japan
Research Site, Kawasaki-shi, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Osakasayama-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Cheongju-si, , Korea, Republic of
Research Site, Incheon, , Korea, Republic of
Research Site, Jinju-si, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Suwon-si, , Korea, Republic of
Research Site, Suwon, , Korea, Republic of
Research Site, Ciudad de México, , Mexico
Research Site, Ciudad de México, , Mexico
Research Site, Culiacan, , Mexico
Research Site, Guadalajara, , Mexico
Research Site, Guadalajara, , Mexico
Research Site, Mexico City, , Mexico
Research Site, Monterrey, , Mexico
Research Site, Naucalpan, , Mexico
Research Site, Amsterdam, , Netherlands
Research Site, Groningen, , Netherlands
Research Site, Nieuwegein, , Netherlands
Research Site, Tilburg, , Netherlands
Research Site, Lublin, , Poland
Research Site, Poznań, , Poland
Research Site, Przemysl, , Poland
Research Site, Rzeszów, , Poland
Research Site, Szklarska Poręba, , Poland
Research Site, Tomaszów Mazowiecki, , Poland
Research Site, Toruń, , Poland
Research Site, Warszawa, , Poland
Research Site, Warszawa, , Poland
Research Site, Łódź, , Poland
Research Site, Banska Bystrica, , Slovakia
Research Site, Bratislava, , Slovakia
Research Site, Bratislava, , Slovakia
Research Site, Kosice, , Slovakia
Research Site, Trnava, , Slovakia
Research Site, Amanzimtoti, , South Africa
Research Site, Bloemfontein, , South Africa
Research Site, George, , South Africa
Research Site, Johannesburg, , South Africa
Research Site, Parktown, , South Africa
Research Site, Pietermaritzburg, , South Africa
Research Site, Pretoria, , South Africa
Research Site, Rondebosch, , South Africa
Research Site, Soweto, , South Africa
Research Site, Alicante, , Spain
Research Site, Barcelona, , Spain
Research Site, Barcelona, , Spain
Research Site, Bilbao (Vizcaya), , Spain
Research Site, Madrid, , Spain
Research Site, Málaga, , Spain
Research Site, Palma, , Spain
Research Site, Hsinchu, , Taiwan
Research Site, Kaohsiung, , Taiwan
Research Site, Tainan, , Taiwan
Research Site, Taipei City, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Yunlin, , Taiwan
Research Site, Lampang, , Thailand
Research Site, Muang, , Thailand
Research Site, Songkhla, , Thailand
Research Site, Ankara, , Turkey
Research Site, Antalya, , Turkey
Research Site, Diyarbakir, , Turkey
Research Site, Istanbul, , Turkey
Research Site, İzmir, , Turkey
Research Site, Pamukkale, , Turkey
Research Site, Çankaya, , Turkey
Research Site, Birmingham, , United Kingdom
Research Site, Blackpool, , United Kingdom
Research Site, Bury St Edmunds, , United Kingdom
Research Site, Colchester, , United Kingdom
Research Site, London, , United Kingdom
Research Site, London, , United Kingdom
Research Site, London, , United Kingdom
Research Site, London, , United Kingdom
Research Site, Truro, , United Kingdom
Contact Details
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