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Brief Title: EVESOR: a Phase 1 Trial of Everolimus and Sorafenib
Official Title: EVESOR: a Phase 1 Trial of Everolimus and Sorafenib to Assess the Impact of Doses and Administration Sequences on Pharmacokinetic and Pharmacodynamic Effects of the Combination
Study ID: NCT01932177
Brief Summary: EVESOR multiparameter phase I trial aims at determining the safety of different doses and dosing schedules of everolimus in combination with sorafenib as well as the recommended doses \& dosing schedules for phase 2 trials in adult patients with advanced solid tumors.
Detailed Description: The present phase I trial aims at determining the safety of different doses and dosing schedules of everolimus in combination with sorafenib as well as the recommended doses \& dosing schedules for phase 2 trials in adult patients with advanced solid tumors.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Hospices Civils de Lyon, Lyon, , France
Name: BENOIT YOU, MD PhD
Affiliation: Hospices Civils de Lyon
Role: STUDY_DIRECTOR