Spots Global Cancer Trial Database for A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
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Trial Identification
Brief Title: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
Official Title: A Phase Ib, Open-Label, Multicenter Dose-Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Patients With Locally Advanced or Metastatic Solid Tumors
Study ID: NCT05867121
Study Description
Brief Summary: The purpose of this study is to evaluate the safety and tolerability of RO7496353 when administered in combination with a checkpoint inhibitor (CPI) with or without standard-of-care (SOC) chemotherapy in participants with locally advanced or metastatic solid tumors such as non-small cell lung cancer (NSCLC), gastric cancer (GC) and pancreatic ductal adenocarcinoma (PDAC). The study will be conducted in 2 stages: an initial safety run-in stage and an expansion stage.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
UCLA University of California Los Angeles, Los Angeles, California, United States
Yale School of Medicine, New Haven, Connecticut, United States
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
St Vincent'S Hospital, Darlinghurst, New South Wales, Australia
Flinders Medical Centre, Bedford Park, South Australia, Australia
Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS), Porto Alegre, RS, Brazil
Fondazione Policlinico Universitario A Gemelli, Roma, Lazio, Italy
Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Veneto, Italy
National Cancer Center Hospital East, Chiba, , Japan
Kanagawa Cancer Center, Kanagawa, , Japan
Shizuoka Cancer Center, Shizuoka, , Japan
National Cancer Center Hospital, Tokyo, , Japan
The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo, , Japan
Seoul National University Hospital, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center - PPDS, Seoul, , Korea, Republic of
Severance Hospital Yonsei University Health System - Clinical Trials Center Pharmacy, Seoul, , Korea, Republic of
Auckland City Hospital, Auckland, , New Zealand
NEXT Oncology-Hospital Quironsalud Madrid, Pozuelo de Alarcon, Madrid, Spain
Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
Clinica Universidad de Navarra-Madrid, Madrid, , Spain
Hospital Clinico Universitario de Valencia, Valencia, , Spain
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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