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Brief Title: Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer
Official Title: A Randomized, Double Blind, Phase 3 Study of Platinum-Based Chemotherapy With or Without INCMGA00012 in First-Line Metastatic Squamous and Nonsquamous Non-Small Cell Lung Cancer (POD1UM-304)
Study ID: NCT04205812
Brief Summary: The purpose of this study is to assess the efficacy and safety of platinum-based chemotherapy with or without INCMGA00012 in participants with metastatic squamous and nonsquamous non-small cell lung cancer (NSCLC).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Pacific Cancer Medical Center, Anaheim, California, United States
Innovative Clinical Research Institute, Whittier, California, United States
Reading Hospital and Medical Center, Reading, Pennsylvania, United States
Fundacao Pio Xii Hospital de Cancer de Barretos, Barretos, , Brazil
Incan - Instituto Do Cancer - Hospital Pompeia, Caxias Do Sul, , Brazil
Centro Regional Integrado de Oncologia, Fortaleza, , Brazil
Oncosite - Centro de Pesquisa Clinica E Oncologia, Ijui, , Brazil
Clinica de Neoplasias Litoral Ltda, Itajai, , Brazil
Hospital Do Cancer de Londrina, Londrina, , Brazil
Instituto Mederi de Pesquisa E Saude, Passo Fundo, , Brazil
Hgb - Hospital Giovanni Battista - Mae de Deus Center, Porto Alegre, , Brazil
Inca - Instituto Nacional de Cancer, Rio de Janeiro, , Brazil
Sao Camilo Oncologia, S?O Paulo, , Brazil
Cepho - Centro de Estudos E Pesquisas de Hematologia E Oncologia, Santo Andre, , Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, Sao Jose, , Brazil
Mc Women'S Health-Nadezhda Eood, Sofia, , Bulgaria
Acibadem Cityclinica Mhat Tokuda, Sofia, , Bulgaria
Umhat Sv. Ivan Rilski Ead, Sofia, , Bulgaria
Mhat Serdika Eood, Sofia, , Bulgaria
Multiprofile Hospital For Active Treatment Central Onco Hospital Ood, Sofia, , Bulgaria
Shatod Dr Marko Marko - Varna Ltd, Varna, , Bulgaria
Hunan Cancer Hospital, Changsha, , China
The First Affiliated Hospital Sun Yat-Sen University, Guangzhou, , China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, , China
Hangzhou Cancer Hospital, Hangzhou, , China
The First Affiliated Hospital of Zhejiang University, Hangzhou, , China
Zhejiang Cancer Hospital, Hangzhou, , China
Harbin Medical University Cancer Hospital, Harbin, , China
University of Science and Technology of China-First Affiliated Hospital (Anhui Provincial Hospital), Hefei, , China
The Second Hospital of Anhui Medical University, Hefei, , China
Jinan Central Hospital, Jinan, , China
Linyi Cancer Hospital, Linyi, , China
The Second Affiliated Hospital of Nanchang University, Nanchang, , China
The First Affiliated Hospital of Guangxi Medical University, Nanning, , China
Shanghai Chest Hospital, Shanghai, , China
General Hospital of Tianjin, Tianjing, , China
The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, , China
Henan Cancer Hostipal, Zhengzhou, , China
Henan Provincial Peoples Hospital, Zhengzhou, , China
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, , China
University Hospital Hradec Kralove, Hradec Kralove, , Czechia
Fakultni Nemocnice Olomouc, Olomouc, , Czechia
Nemocnice Agel Ostrava - Vitkovice A.S, Ostrava - Vitkovice, , Czechia
Fakultni Nemocnice V Motole, Praha 5, , Czechia
High Technology Hospital Medcenter, Batumi, , Georgia
Jsc Evex Hospitals, Kutaisi, , Georgia
Archangel St. Michael Multi Profile Clinical Hospital, Tbilisi, , Georgia
Israel-Georgian Medical Research Clinic Helsicore, Tbilisi, , Georgia
New Hospitals, Tbilisi, , Georgia
Medulla Chemotherapy and Immunotherapy Clinic, Tbilisi, , Georgia
Tbilisi State Medical University First University Clinic, Tbilisi, , Georgia
High Technology Medical Center, University Clinic, Tbilisi, , Georgia
Institute of Clinical Oncology Ltd, Tbilisi, , Georgia
Cancer Research Center Ltd, Tbilisi, , Georgia
Orszagos Koranyi Tbc Es Pulmonological Intezet, Budapest, , Hungary
Bacs Kiskun Megyei Oktatokorhaz, Kecskemet, , Hungary
Advanced Medical and Dental Institute Husm, Kepala Batas, , Malaysia
University Malaya Medical Centre, Kuala Lumpur, , Malaysia
Hospital Tengku Ampuan Afzan, Kuantan, , Malaysia
Sarawak General Hospital, Kuching, , Malaysia
Beacon Hospital Sdn Bhd, Petaling Jaya, , Malaysia
Hospital Pulau Pinang, Pulau Pinang, , Malaysia
Institut Kanser Negara - National Cancer Institute, Putrajaya, , Malaysia
Cebu Doctors University Hospital, Cebu City, , Philippines
Davao Doctors Hospital, Davao City, , Philippines
West Visayas State University Medical Center, Iloilo City, , Philippines
Makati Medical Center, Makati City, , Philippines
Makati Medical Center, Makati, , Philippines
Philippine General Hospital, Manila, , Philippines
Asian Hospital and Medical Center, Muntinlupa, , Philippines
The Medical City, Pasig City, , Philippines
St. Lukes Medical Center, Quezon City, , Philippines
Ko-Med Centra Kliniczne Biala Podlaska, Biala Podlaska, , Poland
Przychodnia Lekarska Komed, Konin, , Poland
Centrum Medyczne Plejady, Krakow, , Poland
Centrum Terapii Wspolczesnej J.M. Jasnorzewska Sp. Komandytowo-Akcyjna, Lodz, , Poland
Przychodnia Med-Polonia Sp. Z O.O., Poznan, , Poland
S.C Oncopremium Team S.R.L, Baia Mare, , Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, Cluj Napoca, , Romania
Spitalul Clinic Militar de Urgenta Dr. Constantin Papilian Cluj-Napoca, Cluj-napoca, , Romania
Spitalul Clinic Judetean de Urgenta Constanta, Constanta, , Romania
S C Oncocenter Oncologie Medicala S R L, Timisoara, , Romania
Oncomed Srl, Timisoara, , Romania
Sbih of Arkhangelsk Region Arkhangelsk Clinical Oncological Dispensary, Arkhangelsk, , Russian Federation
Rbih Kursk Regional Clinical Oncology Dispensary of Kursk Region Healthcare Committee, Kursk, , Russian Federation
Federal State Institution "Russian Cancer Research Center Named After N.N. Blokhin" Rams, Moscow, , Russian Federation
Llc Tonus, Nizniy Novgorod, , Russian Federation
Sbhi of Novosibirsk Region Novosibirsk Regional Oncological Dispensary, Novosibirsk, , Russian Federation
Bhi of Omsk Region Clinical Oncology Dispensary, Omsk, , Russian Federation
Pavlov First Saint Petersburg State Medical University, Saint-petersburg, , Russian Federation
N.N. Petrov Research Institute of Oncology, Saint-petersburg, , Russian Federation
N.N. Petrov Research Institute of Oncology, St Petersburg, , Russian Federation
Sbhi Volgograd Regional Onclogy Dispensary, Volgograd, , Russian Federation
Clinical Center of Serbia, Belgrade, , Serbia
Clinical Center Bezanijska Kosa, Belgrade, , Serbia
Clinical Center of Serbia, Belgrade, , Serbia
Oncomed-System, Belgrad, , Serbia
Clinical Center Kragujevac, Kragujevac, , Serbia
Institute For Pulmonary Diseases of Vojvodina, Sremska Kamenica, , Serbia
Cape Town Oncology Trials (Pty) Ltd, Cape Town, , South Africa
Cancercare Rondebosch Oncology Centre, Cape Town, , South Africa
Wits Clinical Research, Johannesburg, , South Africa
Sandton Oncology Centre, Johannesburg, , South Africa
University of Pretoria Oncology Department, Pretoria, , South Africa
Mary Potter Oncology Centre, Pretoria, , South Africa
Acibadem Adana Hospital, Adana, , Turkey
Adana Sehir Hastanesi, Adana, , Turkey
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara, , Turkey
Dr. Abdurrahman Yurtaslan Onkology Teaching and Research Hospital, Ankara, , Turkey
Memorial Ankara Hospital, Ankara, , Turkey
Yildirim Beyazit University Ankara Ataturk Training and Research Hospital, Ankara, , Turkey
Memorial Antalya Hastanesi, Antalya, , Turkey
Trakya Universitesi Tip Fakultesi, Edirne, , Turkey
Gaziantep University Gaziantep Oncology Hospital, Gaziantep, , Turkey
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul, , Turkey
Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Istanbul, , Turkey
Medipol University Medical Faculty, Istanbul, , Turkey
Izmir Medicalpark Hospital, Izmir, , Turkey
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi, Konya, , Turkey
Inonu Universitesi Turgut Ozal Tip Merkezi, Malatya, , Turkey
Multifield Clinical Hospital No 4, Dnipro, , Ukraine
Ci Carpathian Clinical Oncological Center, Ivano-frankivsk, , Ukraine
Communal Non-Profit Enterprise Regional Center of Oncology, Kharkiv, , Ukraine
V.T.Zaycev Institute of General and Urgent Surgery of National Academy Medical Sciences of Ukraine, Kharkiv, , Ukraine
Kherson Regional Oncologic Dispensary, Kherson, , Ukraine
Pp Ppc Acinus Medical and Diagnostic Centre, Kropyvnytskyi, , Ukraine
Mi Kryviy Rih Center of Dnipropetrovsk Regional Council, Kryvyi Rih, , Ukraine
Kyiv City Clinical Oncological Center, Kyiv, , Ukraine
Medical Center Asklepion Llc, Kyiv, , Ukraine
Ci of Krc Kyiv Regional Oncologic Dispensary, Kyiv, , Ukraine
Volyn Regional Oncological Dispensary, Lutsk, , Ukraine
Rmi Sumy Regional Clinical Oncology Dispensary, Sumy, , Ukraine
Cne Ccch of Uzh Cc Oncological Center, Uzhgorod, , Ukraine
Medical Center Oncolife Llc, Zaporizhzhia, , Ukraine
Can Tho Oncology Hospital, Can Tho, , Vietnam
103 Military Hospital, Hanoi, , Vietnam
Bach Mai Hospital, Hanoi, , Vietnam
Hanoi Oncology Hospital, Hanoi, , Vietnam
National Cancer Hospital, Hanoi, , Vietnam
National Lung Hospital, Hanoi, , Vietnam
Hcmc Oncology Hospital, Ho Chi Minh City, , Vietnam
Name: Incyte Medical Monitor
Affiliation: Incyte Corporation
Role: STUDY_DIRECTOR