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Brief Title: A Study of Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread
Official Title: A Phase 2 Clinical Trial of Nivolumab, or Nivolumab Combinations in Recurrent and Metastatic Microsatellite Instability High (MSI-H) and Non-MSI-H Colon Cancer
Study ID: NCT02060188
Brief Summary: The purpose of this study is to examine if Nivolumab by itself, or Nivolumab in combination with other anti-cancer drugs, will result in meaningful tumor size reduction, in participants with colon cancer that has come back or has spread, and who have a specific biomarker in their tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0028, Gilbert, Arizona, United States
Local Institution - 0004, Los Angeles, California, United States
Local Institution - 0001, San Francisco, California, United States
Local Institution - 0008, Atlanta, Georgia, United States
Local Institution - 0002, Boston, Massachusetts, United States
Local Institution - 0036, Boston, Massachusetts, United States
Allina Health System dba Virginia PIper Cancer Institute, Minneapolis, Minnesota, United States
Local Institution - 0034, Minneapolis, Minnesota, United States
Local Institution - 0024, Durham, North Carolina, United States
Local Institution - 0029, Winston-Salem, North Carolina, United States
Local Institution - 0005, Portland, Oregon, United States
Local Institution - 0041, Allentown, Pennsylvania, United States
Local Institution - 0013, Pittsburgh, Pennsylvania, United States
Local Institution - 0006, Nashville, Tennessee, United States
Local Institution - 0003, Houston, Texas, United States
Local Institution - 0040, Westmead, New South Wales, Australia
Local Institution - 0039, Southport, Queensland, Australia
Local Institution - 0037, Melbourne, Victoria, Australia
Local Institution - 0019, Brussels, , Belgium
Local Institution - 0018, Brussels, , Belgium
Local Institution - 0020, Leuven, , Belgium
Local Institution - 0027, Edmonton, Alberta, Canada
Local Institution - 0016, Toronto, Ontario, Canada
Local Institution - 0025, Paris, , France
Local Institution - 0022, Dublin 4, , Ireland
Local Institution - 0023, Dublin 9, , Ireland
Local Institution - 0033, Galway, , Ireland
Local Institution - 0030, Candiolo, Torino, , Italy
Local Institution - 0035, Modena, , Italy
Local Institution - 0032, Padova, , Italy
Local Institution - 0012, Madrid, , Spain
Local Institution - 0010, Madrid, , Spain
Local Institution - 0011, Sevilla, , Spain
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR