Spots Global Cancer Trial Database for Study of Low-Intensity Conditioning for Allogeneic Stem Cell Transplant

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Trial Identification

Brief Title: Study of Low-Intensity Conditioning for Allogeneic Stem Cell Transplant

Official Title: Phase II Trial of Adjuvant Cellular Immunotherapy for High-Risk Hematologic Malignancy After Reduced Intensity Allogeneic Stem Cell Transplantation

Study ID: NCT00143845

Conditions

Multiple Myeloma

Lymphocytic Leukemia, Chronic

Lymphoma, Low-Grade

Interventions

Reduced intensity conditioning

Rapid immunosuppressive taper

Prophylactic donor leukocyte infusions

Study Description

Brief Summary: The purpose of this study is to determine whether a reduced intensity conditioning regimen for stem cell transplant with donor cells will allow the donor cells to be effective without causing health problems.

Detailed Description: In this research study patients will receive dosages of chemotherapy that are lower than the usual dosages. The study will determine whether a shorter duration of immunosuppression will permit the donor cells to be effective against the cancer without causing more severe GVHD (Graft Versus Host Disease). Also to be determined is whether the patient's cancer can be prevented from relapsing after blood stem cell transplant by using prophylactic treatment, giving a donor leukocyte infusion BEFORE a relapse happens. In this research study samples of blood and bone marrow will be analyzed. These samples will be examined to study the cellular production of inflammatory cytokine levels in attempt to be able to predict which patients will have complications like GVHD or relapse.