Spots Global Cancer Trial Database for MMRF Molecular Profiling Protocol
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Trial Identification
Brief Title: MMRF Molecular Profiling Protocol
Official Title: Clinical-grade Molecular Profiling of Patients With Multiple Myeloma and Related Plasma Cell Malignancies
Study ID: NCT02884102
Interventions
Study Description
Brief Summary: This protocol is now being used as screening for the MyDRUG study
Detailed Description: Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Mayo Clinic - Scottsdale, Scottsdale, Arizona, United States
City of Hope, Duarte, California, United States
UCSF Medical Center, San Francisco, California, United States
Mayo Clinic - Jacksonville, Jacksonville, Florida, United States
Emory University, Atlanta, Georgia, United States
University of Chicago, Chicago, Illinois, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan, Ann Arbor, Michigan, United States
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Mayo Clinic - Rochester, Rochester, Minnesota, United States
Washington University, Saint Louis, Missouri, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
Mount Sinai Medical Center, New York, New York, United States
Levine Cancer Institute, Charlotte, North Carolina, United States
Ohio State University, Columbus, Ohio, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Baylor Research Institute, Dallas, Texas, United States
Virginia Cancer Specialists, Fairfax, Virginia, United States
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Contact Details
Name: Leif Bergsagel, M.D.
Affiliation: Mayo Clinic
Role: PRINCIPAL_INVESTIGATOR
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