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Brief Title: Assessment of Efficacy and Safety of Perifosine, Bortezomib and Dexamethasone in Multiple Myeloma Patients
Official Title: A Phase III Randomized Study to Assess the Efficacy and Safety of Perifosine Added to the Combination of Bortezomib and Dexamethasone in Multiple Myeloma Patients
Study ID: NCT01002248
Brief Summary: This is a randomized Phase III study to evaluate the efficacy and safety of perifosine when added to the combination of bortezomib and dexamethasone in multiple myeloma patients who have relapsed on a prior bortezomib treatment regimen.
Detailed Description: A pre-planned interim analysis is expected to take place in Q1 of 2013.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
, La Verne, California, United States
, San Francisco, California, United States
, San Pablo, California, United States
, Aurora, Colorado, United States
, Boulder, Colorado, United States
, Colorado Springs, Colorado, United States
, Denver, Colorado, United States
, Lakewood, Colorado, United States
, Littleton, Colorado, United States
, Longmont, Colorado, United States
, Parker, Colorado, United States
, Pueblo, Colorado, United States
, Thornton, Colorado, United States
, Niles, Illinois, United States
, Winfield, Illinois, United States
, Baltimore, Maryland, United States
, Columbia, Maryland, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
, Morristown, New Jersey, United States
, Great Neck, New York, United States
, Fargo, North Dakota, United States
, Portland, Oregon, United States
, Tualatin, Oregon, United States
, Kingsport, Tennessee, United States
, Bedford, Texas, United States
, Dallas, Texas, United States
, Fort Worth, Texas, United States
, Kerrville, Texas, United States
, San Antonio, Texas, United States
, San Antonio, Texas, United States
, Tyler, Texas, United States
, Ogden, Utah, United States
, Christiansburg, Virginia, United States
, Roanoke, Virginia, United States
, Salem, Virginia, United States
, Seattle, Washington, United States
, Spokane, Washington, United States
, Vancouver, Washington, United States
, Milwaukee, Wisconsin, United States
, Winnipeg, Manitoba, Canada
, Montreal, Quebec, Canada
, Montreal, Quebec, Canada
, Quebec City, Quebec, Canada
, Brno, Czech Republic, Czechia
, Prague, Czech Republic, Czechia
, Dublin 24, , Ireland
Keryx / AOI Pharmaceuticals Investigative Site, Dublin 7, , Ireland
, Dublin 8, , Ireland
, Dublin 9, , Ireland
, Galway, , Ireland
, Limerick, , Ireland
, Sligo, , Ireland
, Tullamore, , Ireland
, Waterford, , Ireland
, Afula, , Israel
, Ashkelon, , Israel
, Beer Sheva, , Israel
, Haifa, , Israel
, Jerusalem, , Israel
, Jerusalem, , Israel
, Nahariya, , Israel
, Petah Tikva, , Israel
, Rehovot, , Israel
, Tel Aviv, , Israel
, Tel-Hashomer, , Israel
, Seoul, , Korea, Republic of
, Seoul, , Korea, Republic of
, Seoul, , Korea, Republic of
, Seoul, , Korea, Republic of
, Seoul, , Korea, Republic of
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Saint Petersburg, , Russian Federation
, Saint Petersburg, , Russian Federation
, Samara, , Russian Federation
, Kosice, Slovak Republic, Slovakia
, Badalona, , Spain
, Barcelona, , Spain
, Barcelona, , Spain
, Barcelona, , Spain
, La Laguna, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Pamplona, , Spain
, Valencia, , Spain
, Zaragoza, , Spain
Name: Paul Richardson, MD
Affiliation: Dana-Farber Cancer Institute
Role: PRINCIPAL_INVESTIGATOR