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Spots Global Cancer Trial Database for COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide

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Trial Identification

Brief Title: COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide

Official Title: Phase Ib/II Trial Of Iberdomide-Combinations In Patients With Positive Minimal Residual Disease (>10-5) After Autologous Hematopoietic Cell Transplantation In The Upfront Management Of Patients With Multiple Myeloma

Study ID: NCT05434689

Study Description

Brief Summary: Similar to the paradigm established in other hematologic malignancies that are considered curable, the achievement of MRD(-) status is necessary for long term disease control in MM. The fact that the majority of patients remain MRD (+) after induction therapy and AHCT points to the opportunity to deploy novel agents with complementary mechanism of action and favorable toxicity profile to reach and maintain MRD (-) status. Given its favorable toxicity profile, the convenience of oral administration, and compelling single agent activity even in heavily pretreated MM, iberdomide is likely amenable to long term therapy in patients with high-risk of relapse/progression identified by the persistence of MRD(+). The investigators intend to develop combination(s) of iberdomide with other agents with complementary mechanism of action in the consolidation setting post AHCT in order to achieve and sustain MRD (-).

Detailed Description:

Keywords

Eligibility

Minimum Age: 19 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Alabama at Birmingham, Birmingham, Alabama, United States

Duke University, Durham, North Carolina, United States

Ohio State University Medical College, Columbus, Ohio, United States

Oregon Health and Science University, Portland, Oregon, United States

Vanderbilt University Medical College, Nashville, Tennessee, United States

University of Wisconsin, Madison, Wisconsin, United States

Contact Details

Name: Luciano Costa, MD, PhD

Affiliation: University of Alabama at Birmingham

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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