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Spots Global Cancer Trial Database for Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma

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Trial Identification

Brief Title: Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma

Official Title: A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma Using a Conditioning Regimen of Fludarabine, Melphalan, and Bortezomib

Study ID: NCT01453101

Study Description

Brief Summary: The hypothesis for this study is that the regimen consisting of fludarabine, melphalan and bortezomib improves the progression free survival and the response rate compared to historical controls of fludarabine and melphalan alone.

Detailed Description: Multiple myeloma is the second most prevalent blood cancer (10%) after non-hodgkin's lymphoma. It represents approximately 1% of all cancers and 2% of all cancer deaths. Although the peak age of onset of multiple myeloma is 70 years of age, recent statistics indicate both increasing incidence and earlier age of onset. The historical control 2-year progression-free survival (PFS) is assumed to be 35%. The proposed therapy of fludarabine, melphalan and bortezomib is expected to improve the PFS by 20%.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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