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Spots Global Cancer Trial Database for AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory Multiple Myeloma

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Trial Identification

Brief Title: AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory Multiple Myeloma

Official Title: A Modular Phase I/II, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Lmmunogenicity, Pharmacodynamics, and Preliminary Efficacy of AZD0305 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Relapsed or Refractory Multiple Myeloma

Study ID: NCT06106945

Interventions

AZD0305

Study Description

Brief Summary: This is a Phase I/II, modular, open-label, multicenter, dose escalation, and dose expansion/optimization study to evaluate the safety, tolerability, PK, immunogenicity, pharmacodynamics, and preliminary efficacy of AZD0305 in participants with RRMM.

Detailed Description: This is a Phase I/II, modular, open-label, multicenter, dose escalation, and dose expansion/optimization study to evaluate the safety, tolerability, PK, immunogenicity, pharmacodynamics, and preliminary efficacy of AZD0305 in participants with RRMM. This study will follow a modular protocol design evaluating AZD0305 as monotherapy and in combination with other anticancer agents. The study includes dose escalation and dose expansion phases. This study will enroll subjects with RRMM who received at least 3 prior lines of treatment including at least one proteasome inhibitor (PI), one immunomodulator (IMiD), and an anti-CD38 antibody. Subjects will be administered AZD0305 intravenously.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Research Site, Duarte, California, United States

Research Site, Irvine, California, United States

Research Site, Ann Arbor, Michigan, United States

Research Site, Saint Louis, Missouri, United States

Research Site, New York, New York, United States

Research Site, Philadelphia, Pennsylvania, United States

Research Site, Fairfax, Virginia, United States

Research Site, Melbourne, , Australia

Research Site, Perth, , Australia

Research Site, Hamilton, Ontario, Canada

Research Site, Montreal, Quebec, Canada

Research Site, Beijing, , China

Research Site, Freiburg, , Germany

Research Site, Hamburg, , Germany

Research Site, Lübeck, , Germany

Research Site, Nürnberg, , Germany

Research Site, Würzburg, , Germany

Research Site, Kashiwa, , Japan

Research Site, Nagoya-shi, , Japan

Research Site, Madrid, , Spain

Research Site, Pamplona, , Spain

Research Site, Salamanca, , Spain

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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