Spots Global Cancer Trial Database for A Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma
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Trial Identification
Brief Title: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma
Official Title: A Phase Ib, Open-label, Multicenter Dose-escalation Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Patients With Relapsed/Refractory Multiple Myeloma
Study ID: NCT05646836
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with cevostamab in participants with relapsed/refractory multiple myeloma (R/R MM) who have received a minimum of three prior treatments, including at least one immunomodulatory drug (IMiD), one proteasome inhibitor (PI), and one anti-CD38 monoclonal antibody.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Peter Maccallum Cancer Centre, Melbourne, Victoria, Australia
Alfred Hospital, Melbourne, Victoria, Australia
Sygehus Lillebaelt - Vejle Sygehus, Vejle, , Denmark
Evangelismos General Hospital of Athens, Athens, , Greece
University of Athens Medical School - Regional General Hospital Alexandra, Athens, , Greece
Rabin Medical Center-Beilinson Campus, Petach Tikva, , Israel
Tel Aviv Sourasky Medical Center PPDS, Tel Aviv-Yafo, , Israel
Severance Hospital, Yonsei University, Seoul, , Korea, Republic of
Asan Medical Center - PPDS, Seoul, , Korea, Republic of
Oslo University Hospital Rikshospitalet, Oslo, , Norway
Clinica Universidad de Navarra, Pamplona, Navarra, Spain
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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