Spots Global Cancer Trial Database for MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb
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Trial Identification
Brief Title: MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb
Official Title: MAGNETISMM-3 AN OPEN-LABEL, MULTICENTER, NON-RANDOMIZED PHASE 2 STUDY OF ELRANATAMAB (PF-06863135) MONOTHERAPY IN PARTICIPANTS WITH MULTIPLE MYELOMA WHO ARE REFRACTORY TO AT LEAST ONE PROTEASOME INHIBITOR, ONE IMMUNOMODULATORY DRUG AND ONE ANTI-CD38 ANTIBODY
Study ID: NCT04649359
Conditions
Interventions
Study Description
Brief Summary: The purpose of the study is to evaluate whether single-agent Elranatamab (PF-06863135) can provide clinical benefit in participants with relapsed/refractory multiple myeloma. Elranatamab is a bispecific antibody: binding of Elranatamab to CD3-expressing T-cells and BCMA-expressing multiple myeloma cells causes targeted T-cell-mediated cytotoxicity.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Beverly Hills Cancer Center, Beverly Hills, California, United States
UCLA Hematology/Oncology Clinic, Los Angeles, California, United States
UCLA Ronald Reagan Medical Center, Los Angeles, California, United States
UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange, California, United States
Baptist Hospital of Miami, Miami, Florida, United States
Miami Cancer Institute, Miami, Florida, United States
Winship Cancer Institute @ Emory University Hospital Midtown, Atlanta, Georgia, United States
Emory University Hospital, Atlanta, Georgia, United States
Winship Cancer Institute, Emory University, Atlanta, Georgia, United States
Blood and Marrow Transplant Group of Georgia, Atlanta, Georgia, United States
Northside Hospital, Atlanta, Georgia, United States
Northwestern Medical Group, Chicago, Illinois, United States
Northwestern Memorial Hospital, Chicago, Illinois, United States
Loyola University Chicago performing research at Loyola University Medical Center, Maywood, Illinois, United States
Franciscan Health, Indianapolis, Indiana, United States
Indiana Blood and Marrow Transplantation-Administrative Offices, Indianapolis, Indiana, United States
Indiana Blood and Marrow Transplantation-Clinic, Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
Norton Cancer Institute, St. Matthews Campus, Louisville, Kentucky, United States
Norton Women's and Children's Hospital, Louisville, Kentucky, United States
Ochsner Clinic Foundation, New Orleans, Louisiana, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care, New York, New York, United States
Weill Cornell Medical College - New York Presbyterian Hospital, New York, New York, United States
Weill Cornell Medical College - New York-Presbyterian Hospital, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Weill Cornell Medical College - New York Presbyterian Hospital, New York, New York, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
St. Francis Hospital, Greenville, South Carolina, United States
Saint Francis Hospital Cancer Center, Greenville, South Carolina, United States
St Francis Eastside, Greenville, South Carolina, United States
Baylor University Medical Center, Dallas, Texas, United States
Epworth Healthcare, East Melbourne, Victoria, Australia
St Vincent's Hospital (Melbourne), Fitzroy, Victoria, Australia
The Alfred Hospital, Melbourne, Victoria, Australia
The Alfred, Melbourne, Victoria, Australia
Epworth Healthcare, Richmond, Victoria, Australia
ZNA-Middelheim, Antwerpen, , Belgium
ZNA Stuivenberg, Antwerpen, , Belgium
Universitair Ziekenhuis Antwerpen, Edegem, , Belgium
CHU UCL Namur site Godinne, Yvoir, , Belgium
Foothills Medical Centre, Calgary, Alberta, Canada
Tom Baker Cancer Centre, Calgary, Alberta, Canada
Cross Cancer Institute, Edmonton, Alberta, Canada
CIUSSS-EMTL, Installation Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada
Jewish General Hospital, Montreal, Quebec, Canada
McGill University Health Centre - Glen Site, Montreal, Quebec, Canada
CHU de Lille - Hopital Claude Huriez, Lille, , France
CHU de Nantes - Hôtel Dieu, Nantes Cedex 1, , France
Hôpital Saint-Antoine, Paris Cedex 12, , France
Hopital Saint-Louis, Paris, , France
Centre Hospitalier Lyon Sud - Service d'Hematologie Clinique, Pierre Benite Cedex, , France
CHU de Poitiers, Pôle Régional de Cancérologie, Poitiers Cedex, , France
Klinikum Chemnitz gGmbH, Chemnitz, , Germany
Universitätsklinikum Hamburg - Eppendorf, Hamburg, , Germany
Universitätsklinikum Heidelberg, Heidelberg, , Germany
Universitätsklinik Schleswig-Holstein, Kiel, , Germany
Nagoya City University Hospital, Nagoya, Aichi, Japan
Gunma University Hospital, Maebashi, Gunma, Japan
Kobe City Medical Center General Hospital, Kobe-city, Hyogo, Japan
Iwate Medical University Hospital, Yahaba-cho, Shiwa-gun, Iwate, Japan
Tohoku University Hospital, Sendai, Miyagi, Japan
Japanese Red Cross Medical Center, Shibuya-ku, Tokyo, Japan
Yamagata University Hospital, Yamagata, , Japan
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy, Bydgoszcz, , Poland
Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu, Poznan, , Poland
Uniwersytecki Szpital Kliniczny im.Jana Mikulicza -Radeckiego we Wroclawiu, Wroclaw, , Poland
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, A Coruna, Spain
Institut Catala d' Oncologia. Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
Hospital Clinic de Barcelona, Barcelona, , Spain
Clinica Universitaria de Navarra, Madrid, , Spain
Hospital Universitario 12 de Octubre, Madrid, , Spain
Hospital Universitario Doctor Peset, Valencia, , Spain
The Christie NHS Foundation Trust, Manchester, , United Kingdom
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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