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Spots Global Cancer Trial Database for Efficacy and Safety Study of 3 Thalidomide Doses for the Treatment of Relapsed Refractory Multiple Myeloma

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Trial Identification

Brief Title: Efficacy and Safety Study of 3 Thalidomide Doses for the Treatment of Relapsed Refractory Multiple Myeloma

Official Title: Randomised, Controlled, Open-labelled, Multi-centre Comparison of Thalidomide Versus High-dose Dexamethasone for the Treatment of Relapsed Refractory Multiple Myeloma

Study ID: NCT00452569

Study Description

Brief Summary: The primary objective is to compare the time to progression (TTP) of three daily doses of thalidomide (100, 200 and 400 mg) with high-dose dexamethasone in relapsed refractory multiple myeloma (MM) patients and to subsequently select the optimum thalidomide dose in terms of median TPP and toxicity.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Clinic of Haematology, University Multiprofiled Hospital for Active Treatment "G. Stranski", Pleven, , Bulgaria

Clinic of Haematology, University Multiprofiled Hospital for Active Treatment, Plovdiv, , Bulgaria

University of Multiprofiled Hospital for Active Treatment "Alexandrovska" - Sofia, Sofia, , Bulgaria

Military Medical Academy/Dept Haematology and Oncology, Sofia, , Bulgaria

National Center of Haematology & Transfusiology, Sofia, , Bulgaria

Clinic of Haematology, Multiprofiled Hospital for Active Treatment "Sveta Marina", Varna, , Bulgaria

Klinicki Bolnicki Centar Rijeka Interna Klinika, Rijeka, , Croatia

Klinika Bolnica SPLIT - Klinika za Unutarnje Bolesti, Split, , Croatia

KBC Zagreb - Klinika za Unutarnje Bolesti, Zagreb, , Croatia

Klinicka Bolnica "Dubrava" Klinika za Unutarnje Bolesti, Zagreb, , Croatia

Klinicka Bolnica "Sestre milosrdnice" Klinika za Unutarnje Bolesti, Zagreb, , Croatia

Klinicka Bolnica MERKUR - Klinika za Unutarnje Bolesti, Zagreb, , Croatia

Interni Hemato-Onkologicka Klinika, Brno, , Czechia

Hematologicka Klinika, Fakultni Nemocnice Hradec Kralove, Hradec Kralove, , Czechia

Onkologicke Centrum J.G. Mendela, Novi Jicin, , Czechia

Interni Klinika, Oddeleni Hematoonkologie, Olomouc, , Czechia

Hematologicka Klinika, Fakultni Nemocnice Kralovske Vinohrady Srobarova, Prague 10, , Czechia

Interni Klinika, Oddeleni Hematoonkologie, Prague 2, , Czechia

CHRU de Lille - Hopital Claude Huriez, Lille, , France

CHU de Nancy - Hopital Brabois, Nancy Cedex, , France

Hematologie - CHU Purpan Place du Dr. Baylac, Toulouse, , France

Charite, Universitatsmedizin Berlin, Campus Robert-Rossle Klinik, Berlin, , Germany

Med. Klinik I/University Bonn, Bonn, , Germany

Medizinische Klinik und Poliklinik I/Carl-Gustav-Carus University, Dresden, , Germany

Hematology, Oncology & Clinical Immunology/Heinrich-Heine-University, Duesseldorf, , Germany

Abt. Haematologie - Onkologie/ Allg. Krankenhaus, Hamburg, , Germany

Allgemeinse Krankenhaus St. Georg Hamatologische Abteilung, Hamburg, , Germany

Medizinische Klinik Abteilung Innere V/Universitatsklinikum, Heidelberg, , Germany

Universitat Schleswig Holstein II Med. Klinik, Kiel, , Germany

Universitaetsklinik - Klinik fur innere Medizin, Koeln, , Germany

Medizinische Klinik und Poliklinik III/Klinikum der Universitaet Muenchen, Muenchen, , Germany

Innere Medizin University Hospital, Muenster, , Germany

Abteilung Haematologie - Univeresitaetsklinikum, Saale, , Germany

Robert-Bosch-Krankenhaus GmbH, Stuttgart, Stuttgart, , Germany

Universitaetsklinik - Abteilung Innere Medizin III, Ulm, , Germany

Med. Klinik II/Klinikum of the Julius-Maximilians-University, Wuerzburg, , Germany

National Medical Centre Dpt Haematology, Budapest, , Hungary

Petz Aladar Megyei Oktato Korhaz, II. Belgyogyaszat, Gyor, , Hungary

Pandy Kalman Megyei Korhaz, Megyei Onkologiai Centrum, Gyula, , Hungary

Szent-Gyorgyi Albert University II Clinic of Internal Medicine, Szeged, , Hungary

Nizam's Institute of Medical Sciences, Department of Medical Oncology, Hyderabaad, , India

Department of Medical Oncology, Amrita Institute of Medical Sciences, Kerala, , India

Orchid Nursing Home, Kolkata, , India

Department of Medical Oncology, Dayanand Medical College DMCH, Ludhiana, , India

Department of Medical Oncology/Tata Memorial Hospital, Mumbai, , India

Department of Medical Oncology, S.L. Raheja Hospital, Mumbai, , India

Department of Medical Oncology, Jaslok Hospital and Research Centre, Mumbai, , India

Department of Medical Oncology, Deenanath Mangeshkar Hospital, Pune, , India

Department of Medical Oncology/Regional Cancer Centre, Trivandrum, , India

Instituto di Ematologia e Oncologia Medica, Bologna, , Italy

Dipartimento Medicina ed Oncologia Sperimentale - Divisione Universitaria di Ematologia Azienda Ospedaliera S. Giovanni Battista, Torino, , Italy

Department of Internal Medicine - Baguio General Hospital & Medical Center, Baguio City, , Philippines

Chong Hua Hospital, Cebu City, , Philippines

Doctors Clinic Makati Medical Center, Makati City, , Philippines

University of Sto Tomas Hospital, Manila City, , Philippines

Doctors Clinic - National Kidney & Transplant Institute, Quezon City, , Philippines

St. Luke's Medical Center, Quezon City, , Philippines

SPSK, Klinika Hematologii Akademii Medycznej, Bialystok, , Poland

Klinika Hematologii Akademii Medycznej w Gdanskuul, Gdansk, , Poland

Katedra i Klinika Hematologii i Transplantacji Szpiku - Slaska Akademia Medyczna, Katowice, , Poland

Swietokrzyskie Centrum Onkologii SPZOZ Poradnia Hematologii, Kielce, , Poland

Klinika Hematologii Uniwersytetu Medycznego, Lodz, , Poland

Klinika Chorob Wewnetrznych i Hemagologii, Warszawa, , Poland

Katedra i Klinika Hematologii, Onkologii I Chorob Wewnetrznych, Warszawa, , Poland

Instytut Hematologii i Transfuzjologii - Klinika Hematologiczna, Warszawa, , Poland

Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie, Warszawa, , Poland

Klinika Hematologii Nowotworow Krwi i Transplantacji - Szpiku Akademii Medycznej, Wroclaw, , Poland

Hospital da Universidade de Coimbra - Servico de Hematologia Clinica, Coimbra, , Portugal

Instituto Portugues de Oncologia, Lisboa, , Portugal

Hospital Geral de Santo Antonio - Servico de Hematologia Clinica, Porto, , Portugal

Institute of Hematology, Clinical Centre of Serbia, Belgrade, , Serbia

Clinic for Hematology, Clinical Centre Nis, Nis, , Serbia

Clinic for Hematology, Clinical Centre Novi Sad, Novisad, , Serbia

Department of Internal Medicine, National Cancer Institute, Bratilslava, , Slovakia

Hematology Department University Hospital, Bratilslava, , Slovakia

Hematology Department, University Hospital PJS, Kosice, , Slovakia

University of Free State, Faculty of Health Science, Dept of Hematology & Cell Biology, Bloemfontein, , South Africa

Tygerberg Hospital, University of Stellenbosch, Department of Haematology, Cape Town, , South Africa

Department of Haematology, UCT Medical School, Cape Town, , South Africa

Chris Hani Baragwanath Hospital, Clinical Haematology Unit, Johannesburg, , South Africa

Medical Oncology Centre of Rosebank, Johannesburg, , South Africa

Johannesburg Hospital, Department of Medical Oncology, Parktown, , South Africa

Oncology Research Unit Heartlands Hospital, Birmingham, , United Kingdom

Clinical Haematology, Guy's Hospital, London, , United Kingdom

Haematology Department - King's College Hospital, London, , United Kingdom

Department of Haematology-Oncology, The Royal Marsden NHS Foundation Trust, Surrey, , United Kingdom

Contact Details

Name: Martin Kropff, MD

Affiliation: Universitatsklinikum Munster

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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