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Brief Title: A Safety and Efficacy Study Evaluating CTX120 in Subjects With Relapsed or Refractory Multiple Myeloma
Official Title: A Phase 1 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Anti-BCMA Allogeneic CRISPR-Cas9-Engineered T Cells (CTX120) in Subjects With Relapsed or Refractory Multiple Myeloma
Study ID: NCT04244656
Brief Summary: This is a single-arm, open-label, multicenter, Phase 1 study evaluating the safety and efficacy of CTX120 in subjects with relapsed or refractory multiple myeloma.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Chicago, Chicago, Illinois, United States
Oregon Health and Science University, Portland, Oregon, United States
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Institut Catala d'Oncologia Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Universidad de Navarra, Pamplona, Navarra, Spain
Hospital Universitario de Salamanca, Salamanca, , Spain
Name: Annie Weaver, PhD
Affiliation: CRISPR Therapeutics
Role: STUDY_DIRECTOR