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Brief Title: Autologous CD8+ T-cells Expressing an Anti-BCMA CAR in Patients With Myeloma
Official Title: Combined Phase I-Phase II Study of Autologous CD8+ T-cells Transiently Expressing a Chimeric Antigen Receptor Directed to B-Cell Maturation Antigen in Patients With Multiple Myeloma
Study ID: NCT03448978
Brief Summary: This Phase I/II study will test the safety and anti-myeloma activity of ascending doses of Descartes-08 (autologous CD8+ T-cells expressing an anti-BCMA chimeric antigen receptor) in eligible patients with active multiple myeloma.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
The Center for Cancer and Blood Disorders, Bethesda, Maryland, United States
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Virgina Cancer Specialists, Fairfax, Virginia, United States
Name: Metin Kurtoglu, MD, PhD
Affiliation: Cartesian Therapeutics
Role: STUDY_DIRECTOR