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Brief Title: Viral Immunotherapy in Relapsed/Refractory Multiple Myeloma
Official Title: VIRel: Viral Immunotherapy in Relapsed/Refractory Multiple Myeloma - A Phase I Study to Assess the Safety and Tolerability of REOLYSIN® (Pelareorep) in Combination With Lenalidomide or Pomalidomide
Study ID: NCT03015922
Brief Summary: This study will recruit patients currently receiving either lenalidomide or pomalidomide whose disease is relapsing. This is a dose escalation study and the aim is to determine the maximum tolerated dose (MTD) of REOLYSIN® that can be given in combination with lenalidomide or pomalidomide. The study will also investigate the safety, side effects and effectiveness of this treatment combination. Pomalidomide and lenalidomide will be evaluated separately as two separate groups.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
St James's University Hospital, Leeds, , United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital, Sheffield, , United Kingdom
Name: Gordon Cook
Affiliation: St. James's University Hospital
Role: PRINCIPAL_INVESTIGATOR