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Spots Global Cancer Trial Database for IV Busulfan Plus Bortezomib Conditioning Regimen for Second Autologous Stem Cell Transplant in Multiple Myeloma Patients

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Trial Identification

Brief Title: IV Busulfan Plus Bortezomib Conditioning Regimen for Second Autologous Stem Cell Transplant in Multiple Myeloma Patients

Official Title: A Phase 2a Study of Once Daily Intravenous Busulfan With Bortezomib, Followed by an Autologous Hematopoietic Stem Cell Transplant (HSCT) in Subjects With Relapsed Multiple Myeloma After Prior Autologous HSCT

Study ID: NCT01009840

Study Description

Brief Summary: Study for the outcome and safety of individualized busulfan dosing with bortezomib for patients preparing for a second stem cell transplant to treat multiple myeloma.

Detailed Description: Evaluation of six-month response in relapsed multiple myeloma subjects, who have had a prior autologous HSCT (greater than one year previously) receiving an IV busulfan-based conditioning regimen with the combination of pharmacokinetic (PK)-guided IV busulfan dosing and bortezomib, followed by a second autologous HSCT. Assessment of the safety profile of this conditioning regimen will also be completed.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Arizona Cancer Center, Tucson, Arizona, United States

Blood and Marrow Transplant Group of Georgia, Atlanta, Georgia, United States

Loyola University Medical Center, Maywood, Illinois, United States

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

University of Maryland School of Medicine - Marlene & Stewart Greenebaum Cancer Center, Baltimore, Maryland, United States

Karmanos Cancer Institute, Detroit, Michigan, United States

University of Pennsylvania -Abramson Cancer Center, Philadelphia, Pennsylvania, United States

The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, United States

South Texas Veterans Health Care System, San Antonio, Texas, United States

Texas Transplant Physician Group, PLLC, San Antonio, Texas, United States

Huntsman Cancer Institute, Salt Lake City, Utah, United States

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

Princess Margaret Hospital, Toronto, Ontario, Canada

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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