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Brief Title: Open-label Study of the Safety and Activity of Oprozomib in Patients With Hematologic Malignancies
Official Title: Phase 1b/2, Multicenter, Open-label Study of the Safety and Activity of Oprozomib in Patients With Hematologic Malignancies
Study ID: NCT01416428
Brief Summary: The purpose of this study is to determine the maximum tolerated dose (MTD), activity, and safety of oprozomib in patients with hematologic malignancies.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Mayo Clinic Scottsdale, Scottsdale, Arizona, United States
Pacific Cancer Care, Salinas, California, United States
Colorado Blood Cancer Institute, Denver, Colorado, United States
Mayo Clinic, Jacksonville, Florida, United States
Winship Cancer Institute, Emory University, Atlanta, Georgia, United States
Rush University Medical Center, Chicago, Illinois, United States
University of Chicago Medical Center, Chicago, Illinois, United States
University of Maryland, Greenebaum Cancer Center, Baltimore, Maryland, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Mass General Hospital, Boston, Massachusetts, United States
Virginia Piper Cancer Institute, Minneapolis, Minnesota, United States
Mayo Clinic, Rochester, Minnesota, United States
Washington University School of Medicine Division of Oncology, Saint Louis, Missouri, United States
John Theurer Cancer Center at Hackensack University, Hackensack, New Jersey, United States
Hematology Oncology of Northern New Jersey, Morristown, New Jersey, United States
New York Oncology Hematology, Albany, New York, United States
Mount Sinai Medical Center, New York, New York, United States
Sarah Cannon Research Institute / Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Columbia Basin Hematology and Oncology, Kennewick, Washington, United States
Name: MD
Affiliation: Amgen
Role: STUDY_DIRECTOR