Spots Global Cancer Trial Database for Autophagy Induction After Bortezomib for Myeloma

Study Description

Brief Summary: The purpose of this study is to better understand the effects of the chemotherapy medication bortezomib on cancer cells. The investigators are therefore taking blood and bone marrow samples from patients with myeloma who are receiving bortezomib to see if the investigators can detect autophagy in the myeloma cells from the bone marrow and in immune cells in the blood. Subjects are eligible if their doctor is planning to treat them with bortezomib for the first time for their myeloma.

Detailed Description: PRIMARY OBJECTIVE: The primary objective of this study is to determine whether administration of bortezomib leads to an increase in cellular autophagy, as determined by electron micrographs of peripheral blood lymphocytes and primary myeloma cells in patients receiving single-agent bortezomib. SECONDARY OBJECTIVES 1. To determine the optimal timing of autophagy assessments for patients receiving bortezomib. 2. To explore whether high levels of autophagy are associated with resistance to bortezomib therapy. 3. To validate our primary assay by confirming baseline stability of the number of autophagic vesicles per cell 4. To compare results of autophagy measurements in peripheral blood mononuclear cells and bone marrow plasma cells

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Contact Details

Useful links and downloads for this trial