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Brief Title: Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)
Official Title: Autologous T-Cells Expressing A Chimeric Antigen Receptor Directed To B-Cell Maturation Antigen (BCMA) In Patients With Generalized Myasthenia Gravis (MG)
Study ID: NCT04146051
Brief Summary: This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Profound Research, Carlsbad, California, United States
University of California Irvine, Irvine, California, United States
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
SFM Clinical Research, LLC, Boca Raton, Florida, United States
Neurology Associates, P.A., Orlando, Florida, United States
University of South Florida, Tampa, Florida, United States
University of Augusta, Augusta, Georgia, United States
University of Kansas Medical Center Research Institute, Kansas City, Kansas, United States
Dent Neurologic Institute, Amherst, New York, United States
University of North Carolina, Chapel Hill, North Carolina, United States
Oregon Health & Science University, Portland, Oregon, United States
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Allegheny Health Network, Pittsburgh, Pennsylvania, United States
Virginia Commonwealth University, Richmond, Virginia, United States
University of Alberta, Edmonton, Alberta, Canada