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Brief Title: Therapy of Antibody-mediated Autoimmune Diseases by Bortezomib (TAVAB)
Official Title: Therapy of Antibody-mediated Autoimmune Diseases by Bortezomib (TAVAB)
Study ID: NCT02102594
Brief Summary: The aim of this pilot study is to investigate the application of proteasome inhibitor Bortezomib (Velcade®, approved for therapy of multiple myeloma) in patients with therapy-refractory antibody-mediated autoimmune diseases. The investigators hypothesis is that the proteasome inhibition will lead to reduced antibody titers and improved clinical outcome.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Charite - Universitätsmedizin Berlin, NeuroCure Clinical Research Center, Berlin, , Germany
Charité - Universitätsmedizin Berlin, Internal Medicine / Rheumathology, Berlin, , Germany
Name: Andreas Meisel, Prof. Dr.
Affiliation: Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center
Role: PRINCIPAL_INVESTIGATOR
Name: Falk Hiepe, Prof. Dr.
Affiliation: Charité - Universitätsmedizin Berlin, Internal Medicine / Rheumatology
Role: PRINCIPAL_INVESTIGATOR