Spots Global Cancer Trial Database for Effect of Pyridostigmine (Mestinon) on Muscle Strength in Myasthenia Gravis
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Trial Identification
Brief Title: Effect of Pyridostigmine (Mestinon) on Muscle Strength in Myasthenia Gravis
Official Title: Effect of Pyridostigmine (Mestinon) on Muscle Strength in Myasthenia Gravis
Study ID: NCT03510546
Conditions
Study Description
Brief Summary: A randomized, placebo-controlled, double-blinded cross-over study evaluating and quantifying the effect of pyridostigmine on muscle strength and symptoms in Myasthenia Gravis (MG)
Detailed Description: The study aims to evaluate and quantify the effect of pyridostigmine on symptoms and muscle strength in newly-diagnosed patients and patients on stable medication. Pyridostigmine treatment is initiated in the vast majority of MG patients. No studies have quantified the effect in a randomized trial, and no studies have examined the potential difference in effect in newly diagnosed patients as compared to patients on stable, antimyasthenic medications. The study will investigate the effect in two groups 1. Newly diagnosed, treatment-naive patients. 2. MG patients on stable antimyasthenic medication.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Neurology Aarhus University Hospital, Aarhus, Midtjylland, Denmark
Contact Details
Name: Jan LS Thomsen, MD
Affiliation: Department of Clinical Medicine, Aarhus University
Role: PRINCIPAL_INVESTIGATOR
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