Spots Global Cancer Trial Database for Safety and Efficacy Study of Eculizumab in Patients With Refractory Generalized Myasthenia Gravis
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Trial Identification
Brief Title: Safety and Efficacy Study of Eculizumab in Patients With Refractory Generalized Myasthenia Gravis
Official Title: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Multi-Center Study of Eculizumab in Patients With Generalized Myasthenia Gravis (gMG) Who Have Moderate to Severe Muscle Weakness Despite Treatment With Immunosuppressants
Study ID: NCT00727194
Conditions
Study Description
Brief Summary: The purpose of this study is to determine whether eculizumab is safe and effective in the treatment of patients with generalized myasthenia gravis despite treatment with various immunosuppressants, such as prednisone, methotrexate, Cellcept, cyclosporine, and cyclophosphamide, that are currently available.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Alabama at Birmingham, Birmingham, Alabama, United States
University of California, Irvine, Orange, California, United States
University of California - Davis, Sacramento, California, United States
University of Florida & Shands Neuroscience Institute, Jacksonville, Florida, United States
Emory University, Atlanta, Georgia, United States
Wishard Hospital, Indianapolis, Indiana, United States
University of Kansas Medical Center, Kansas City, Kansas, United States
Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Caritas St. Elizabeths' Medical Center, Boston, Massachusetts, United States
Wayne State University, Detroit, Michigan, United States
Mount Sinai School of Medicine, New York, New York, United States
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Duke University Medical Center, Durham, North Carolina, United States
University Hospitals - Case Medical Center, Cleveland, Ohio, United States
The Ohio State University, Columbus, Ohio, United States
The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
University of Texas Southwestern Medical School, Dallas, Texas, United States
The University of Vermont College of Medicine, Burlington, Vermont, United States
University of Virginia, Charlottesville, Virginia, United States
The Northern Alberta Clinical trials and Research Centre, Edmonton, Alberta, Canada
Institute of Neurological Sciences, Department of Neurology, Southern General Hospital,, Glasgow, , United Kingdom
Institute of Neurology, London, , United Kingdom
Department of Clinical Neurology, West Wing, John Radcliffe Hospital, Oxford, , United Kingdom
Contact Details
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