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Spots Global Cancer Trial Database for Phase I/II Trial of Sodium Stibogluconate in Myelodysplastic Syndrome

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Trial Identification

Brief Title: Phase I/II Trial of Sodium Stibogluconate in Myelodysplastic Syndrome

Official Title: SHP2 as a Therapeutic Target For Myelodysplastic Syndrome: Phase I/II Trial of Sodium Stibogluconate in Myelodysplastic Syndrome

Study ID: NCT01009502

Study Description

Brief Summary: Sodium stibogluconate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. This was originally designed as a phase I/II trial studying the side effects of sodium stibogluconate and how well it works in treating patients with myelodysplastic syndromes. Unfortunately, due to funding issues, the phase II portion was never conducted.

Detailed Description: Patients receive sodium stibogluconate IV over 30 minutes on days 1-5 and 15-19. Treatment repeats every 28 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients who respond to treatment may continue therapy until disease progression. Patients undergo bone marrow aspiration, biopsy, and peripheral blood sample collection periodically for correlative laboratory studies. After completion of study treatment, patients are followed up at 8 weeks. The phase II portion of this trial was never conducted due to lack of funding.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Northwestern University, Chicago, Illinois, United States

Jesse Brown VHA Medical Center, Chicago, Illinois, United States

Contact Details

Name: Elizabeth Eklund, MD

Affiliation: Northwestern University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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